73751-12-9

Upstream product

• 3781-69-9 4-hydroxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester 
• 108-24-7 acetic anhydride 
• 6769-65-9 ethyl 2-(2-acetyl-3-hydroxyphenoxy)acetate 
• 112489-31-3 ethyl (3-acetoxy-2-acetylphenoxy)acetate 
• 699-83-2 2,6-dihydroxylacetophenone 
• 75-36-5 acetyl chloride 

Relevant academic research and scientific papers

SYNTHESIS OF 2-CARBETHOXY-3-METHYL-4-HYDROXYBENZOFURAN DERIVATIVES

A number of 2-carbethoxy-3-methylbenzofuran derivatives were synthetized.A 5,5-gem-dibromo derivative was obtained in the bromination of 2-carbethoxy-3-methyl-4-oxo-4,5,6,7-tetrahydrobenzofuran.Dehydrobromination of this dibromo derivative gave 2-carbethoxy-3-methyl-4-hydroxy-5-bromobenzofuran.Depending on the structure of the starting compound and the brominating agent, the bromine in the bromination of 2-carbethoxy-3-methyl-4-hydroxy- and 4-acetoxybenzofurans with bromine and N-bromosuccinimide is incorporated either in the methyl group or in 5 and 7 positions of the benzofuran ring.The nitration of 2-carbethoxy-3-methyl-4-hydroxybenzofuran and its bromo derivative leads to 5-nitro- and 5,7-dinitrobenzofuran derivatives.The structures of the synthetized benzofuran derivatives were established by means of the PMR spectra.

Benzofuran 2-carboxylic acid esters useful as inhibitors of leukotriene biosynthesis

Compounds of the Formula I: STR1 and pharmaceutically acceptable salts thereof are inhibitors of leukotriene biosynthesis. These compounds inhibit the mammalian 5-lipoxygenase enzyme, thus preventing the metabolism of arachidonic acid to the leukotrienes.