73760-95-9

Upstream product

• 71355-18-5 4-nitrobenzyl (5RS)-2-(2-hydroxyethyl)pen-2-em-3-carboxylate 
• 124-63-0 methanesulfonyl chloride 
• 73760-93-7 3-(2-Methanesulfonyloxy-ethyl)-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 

Downstream Products

• 73761-04-3 4-nitrobenzyl-2-(2-phenylthioethylidene)penam-3-carboxylate 
• 73761-16-7 3-(2-Acetylsulfanyl-ethyl)-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 73760-96-0 4-nitrobenzyl-2-(2-acetylthioethylidene)penam-3-carboxylate 
• 73760-96-0 (2R,5R)-3-[2-Acetylsulfanyl-eth-(Z)-ylidene]-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 4-nitro-benzyl ester 

Relevant academic research and scientific papers

CONVERSION OF CLAVULANIC ACID INTO THIADEOXA NUCLEAR ANALOGUES

1,4-Addition of sulphur nucleophiles to the diene (12) derived via the pen-2-em (5) from clavulanic acid provides the thiadeoxa analogues (14-15).X-ray analysis of the ester (14) shows the thermodynamically stable isomers to have the same relative stereoc