737766-82-4

Upstream product

• 148928-15-8 1-(((9H-fluoren-9-yl)methoxy)carbonyl)piperidine-4-carboxylic acid 
• 433712-58-4 (9H-fluoren-9-yl)methyl 4-(chlorocarbonyl)piperidine-1-carboxylate 
• 489458-36-8 (9H-fluoren-9-yl)methyl 4-(bromoacetyl)piperidine-1-carboxylate 
• 1211875-79-4 9H-fluoren-9-ylmethyl 4-(2-phenyl-1,3-thiazol-4-yl)piperidine-1-carboxylate 
• 942204-53-7 (9H-fluoren-9-yl)methyl 4-(diazoacetyl)piperidine-1-carboxylate 

Relevant academic research and scientific papers

ARYL CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS FOR TREATMENT OF PAIN

The present invention provides compounds that are inhibitors of voltage-gated sodium channels (Nav), in particular Nav 1.7, and are therefore useful for the treatment of diseases treatable by inhibition of these channels, in particular, chronic pain disorders. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

2-ARYLTHIAZOLE DERIVATIVES AS CXCR3 RECEPTOR MODULATORS

The invention encompasses compounds of Formula I or pharmaceutically acceptable salts thereof, which are modulators of the CXCR3 chemokine receptor function useful for the treatment or prevention of pathogenic inflammatory processes, autoimmune diseases or graft rejection processes. Methods of use and pharmaceutical compositions are also encompassed.