737776-65-7Relevant academic research and scientific papers
The novel phosphoramidate derivatives of NSAID 3-hydroxypropylamides: Synthesis, cytostatic and antiviral activity evaluations
Wittine,Benci,Rajic,Zorc,Kralj,Marjanovic,Pavelic,De Clercq,Andrei,Snoeck,Balzarini,Mintas
scheme or table, p. 143 - 151 (2009/04/12)
The target phosphoramidates 5a-e were prepared in one step from 3-hydroxypropyl derivatives 3a-e of nonsteroidal anti-inflammatory drugs (fenoprofen, ketoprofen, ibuprofen, indomethacin, diclofenac). The products 3a-e and 5a-e were evaluated for their cyt
The novel ketoprofenamides: Synthesis and spectroscopic characterization
Zovko, Marijana,Zorc, Branka,Takac, Milena Jadrijevic-Mladar,Metelko, Biserka,Novak, Predrag
, p. 335 - 341 (2007/10/03)
Synthesis of a series of new ketoprofenamides (3a-h) is described. Amide formation was achieved by aminolysis of ketoprofen benzotriazolide (2) with various amines: primary, secondary, hydroxylamine and amino acid β-alanine. The structures of synthesized compounds were characterized by means of IR, 1H and 13C NMR spectroscopies and elemental analysis. The synthesized compounds are potential prodrugs of a well-known NSAID ketoprofen.
