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737823-46-0

di-tert-butyl {[(4-{2-[2-(acetylamino)-1,3-thiazol-5-yl]ethyl}phenyl)amino]methylidene}biscarbamate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 737823-46-0 Structure

  • Basic information

    1. Product Name: di-tert-butyl {[(4-{2-[2-(acetylamino)-1,3-thiazol-5-yl]ethyl}phenyl)amino]methylidene}biscarbamate
    2. Synonyms: di-tert-butyl {[(4-{2-[2-(acetylamino)-1,3-thiazol-5-yl]ethyl}phenyl)amino]methylidene}biscarbamate
    3. CAS NO:737823-46-0
    4. Molecular Formula:
    5. Molecular Weight: 503.623
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 737823-46-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: di-tert-butyl {[(4-{2-[2-(acetylamino)-1,3-thiazol-5-yl]ethyl}phenyl)amino]methylidene}biscarbamate(CAS DataBase Reference)
    10. NIST Chemistry Reference: di-tert-butyl {[(4-{2-[2-(acetylamino)-1,3-thiazol-5-yl]ethyl}phenyl)amino]methylidene}biscarbamate(737823-46-0)
    11. EPA Substance Registry System: di-tert-butyl {[(4-{2-[2-(acetylamino)-1,3-thiazol-5-yl]ethyl}phenyl)amino]methylidene}biscarbamate(737823-46-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 737823-46-0(Hazardous Substances Data)

737823-46-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 737823-46-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,3,7,8,2 and 3 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 737823-46:
(8*7)+(7*3)+(6*7)+(5*8)+(4*2)+(3*3)+(2*4)+(1*6)=190
190 % 10 = 0
So 737823-46-0 is a valid CAS Registry Number.

737823-46-0Relevant articles and documents

Synthesis and SAR study of new thiazole derivatives as vascular adhesion protein-1 (VAP-1) inhibitors for the treatment of diabetic macular edema

Inoue, Takayuki,Morita, Masataka,Tojo, Takashi,Yoshihara, Kousei,Nagashima, Akira,Moritomo, Ayako,Ohkubo, Mitsuru,Miyake, Hiroshi

, p. 1219 - 1233 (2013/03/28)

Vascular adhesion protein-1 (VAP-1), an amine oxidase that is also known as a semicarbazide-sensitive amine oxidase (SSAO), is present in particularly high levels in human plasma, and is considered a potential therapeutic target for various inflammatory diseases, including diabetes complications such as macular edema. In our VAP-1 inhibitor program, structural modifications following high-throughput screening (HTS) of our compound library resulted in the discovery that thiazole derivative 10, which includes a guanidine group, shows potent human VAP-1 inhibitory activity (IC50 of 230 nM; rat IC 50 of 14 nM). Moreover, compound 10 exhibited significant inhibitory effects on ocular permeability in STZ-induced diabetic rats.

THIAZOLE DERIVATIVES AND THEIR USE AS VAP-1 INHIBITORS

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Page 69-70, (2010/02/07)

A compound of the formula (I): R1-NH-X-Y-Z (I) wherein R1 is acyl; X is a bivalent residue derived from optionally substituted thiazole; Y is a bond, lower alkylene or -COHN-; and Z is a groupe of the formulae (II) or (III) wherein R

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