73793-18-7

Upstream product

• 73793-15-4 1,3,5-tri-O-benzoyl-2-O-(tert-butyldimethylsilyl)-α-D-ribofuranose 
• 66-22-8 4-Hydroxy-1H-pyrimidin-2-one 
• 22224-41-5 1,3,5-tri-O-benzoyl-α-D-ribofuranoside 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 54618-11-0 3',5'-di-O-benzoyluridine 
• 79816-17-4 2'-O-(tert-butyldimethylsilyl)-3'-O-benzoyluridine 

Relevant academic research and scientific papers

Synthesis of 2',3'-Differentiated Ribonucleosides via Glycosylation. Reactions with 2-O-Me or 2-O-TBDMS Ribofuranose Derivatives. 1. Pyrimidine Series

The synthesis of 2',3' asymmetrically substituted pyrimidine ribonucleosides in 70-95percent yields by using modified Vorbruggen conditions with "nonparticipating" 2-O-CH3 and 2-O-TBDMS ribofuranoses is described.Such compounds are useful synthons for oligoribonucleotide synthesis, including incorporation of "rare" bases.New and practically useful conditions for placement (using 1,2,4-triazole) and removal (KF/crown ether) of the tert-butyldimethylsilyl (TBDMS) protecting group are also reported.