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Usage

InChI:InChI=1/C12H13FN2O2/c13-7-12(14,11(16)17)5-8-6-15-10-4-2-1-3-9(8)10/h1-4,6,15H,5,7,14H2,(H,16,17)

Upstream product

• 110511-07-4 methyl 2-(fluoromethyl)-3-(3-indolyl)-2-phthalimidopropionate 
• 110510-98-0 dimethyl 2-(fluoromethyl)-2-phthalimidoadipate 
• 110511-00-7 methyl 2-(fluoromethyl)-5-hydroxy-2-phthalimidopentanoate 
• 110510-99-1 methyl 2-(fluoromethyl)-5-oxo-2-phthalimidopentanoate 
• 110510-97-9 α-(fluoromethyl)glutamic acid dimethyl ester 
• 73800-89-2 (fluoromethyl)glutamic acid 
• 110511-13-2 2-(fluoromethyl)tryptophan methyl ester 
• 145919-16-0 dimethyl (2S,3aS,8aR)-8-(phenylsulfonyl)-2-<<2-(trimethylsilyl)ethoxy>methyl>-1,2,3,3a,8,8a-hexahydropyrrolo<2,3-b>indole-1,2-dicarboxylate 
• 145919-18-2 dimethyl (2S,3aS,8aR)-2-(hydroxymethyl)-8-(phenylsulfonyl)-1,2,3,3a,8,8a-hexahydropyrrolo<2,3-b>indole-1,2-dicarboxylate 
• 145814-41-1 dimethyl (2R,3aR,8aS)-8-(phenylsulfonyl)-2-<<2-(trimethylsilyl)ethoxy>methyl>-1,2,3,3a,8,8a-hexahydropyrrolo<2,3-b>indole-1,2-dicarboxylate 
• 145814-46-6 dimethyl (2R,3aR,8aS)-2-(hydroxymethyl)-8-(phenylsulfonyl)-1,2,3,3a,8,8a-hexahydropyrrolo<2,3-b>indole-1,2-dicarboxylate 
• 136057-11-9 dimethyl (2S,3aR,8aS)-8-benzenesulphonyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole-1,2-dicarboxylate 

Relevant academic research and scientific papers

Enantiospecific Syntheses of α-(Fluoromethyl)tryptophan Analogues: Interactions with Tryptophan Hydroxylase and Aromatic L-Amino Acid Decarboxylase

α-Fluoromethyl amino acids are enzyme-activated irreversible inhibitors of amino acid decarboxylases.Aromatic L-amino acid decarboxylase (AADC) is the enzyme responsible for the final step in the biosynthesis of both dopamine and serotonin via decarboxyla

Synthesis and Biological Properties of α-Mono- and α-Difluoromethyl Derivatives of Tryptophan and 5-Hydroxytryptophan

The syntheses of α-mono- amd α-difluoromethyl derivatives of tryptophan and 5-hydroxytryptophan are described.In an attempt to selectively regulate serotonin synthesis, α-(mono- and difluoromethyl)tryptophan were tested in vivo as precusors (or prodrugs)