73809-05-9

Usage

Uses

Used in Diagnostic Applications:
3-EPI-25-HYDROXYVITAMIN D3 is used as a biomarker to determine the status of vitamin D in the body. It helps in assessing the levels of vitamin D, which is crucial for maintaining overall health and preventing deficiencies.
Used in Analytical Chemistry:
3-EPI-25-HYDROXYVITAMIN D3 can be employed as an analytical standard for the quantification of 3-epi-25(OH)D3 molecules in human serum using the LC-MS/MS method. This application aids in accurate measurement and analysis of vitamin D levels in various research and clinical settings.
Used in Pharmaceutical Research:
The epimer metabolite of Calcifediol or 25-hydroxyvitamin D3 (C125700) has potential applications in the development of pharmaceuticals targeting vitamin D-related conditions. Understanding the role of 3-EPI-25-HYDROXYVITAMIN D3 in the body can contribute to the creation of novel treatments and therapies.
Used in Radiolabelled Compounds:
The labelled epimer metabolite of Calcifediol or 25-hydroxyvitamin D3 (C125700) can be utilized in the development of radiolabelled compounds for various medical imaging and diagnostic procedures. These compounds can help in visualizing and understanding the distribution and metabolism of vitamin D in the body.

Upstream product

• 73809-11-7 (S)-3-[(R)-1-((R)-5-Hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidenemethyl]-2,2-dioxo-2,3,4,5,6,7-hexahydro-1H-2λ⁶-benzo[c]thiophen-5-ol 
• 917-54-4 methyllithium 
• 77531-55-6 25-ketovitamin D₃ 
• 100928-03-8 (S)-2-((1R,3aR,4S,7aR)-4-(tert-butyldimethylsilyloxy)-7a-methyloctahydro-1H-inden-1-yl)propan-1-ol 
• 100928-11-8 25,25-(ethylenedioxy)-27-norvitamin D₃ triisopropylsilyl ether 
• 100928-12-9 (R)-4-Methylene-3-[2-[(1R,3aS,7aR)-7a-methyl-1-[(R)-1-methyl-4-(2-methyl-[1,3]dioxolan-2-yl)-butyl]-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-cyclohexanol 
• 100928-10-7 (S,Z)-<2'-<5-((triisopropylsilyl)oxy)-2-methylenecyclohexylidene>ethyl>diphenylphosphine oxide 
• 84985-78-4 (4R,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-4-((R,Z)-1-hydroxy-2-((S)-5-hydroxy-2-methylenecyclohexylidene)ethyl)-7a-methyloctahydro-1H-inden-4-ol 
• 100928-06-1 (R)-6-[(1R,3aR,4S,7aR)-4-(tert-Butyl-dimethyl-silanyloxy)-7a-methyl-octahydro-inden-1-yl]-3-trimethylsilanyl-heptan-2-one 
• 100938-73-6 {(R)-3-[2-Chloro-eth-(Z)-ylidene]-4-methylene-cyclohexyloxy}-triisopropyl-silane 
• 100928-01-6 (S,Z)-2'-<5-<(triisopropylsilyl)oxy>-2-methylenecyclohexylidene>ethanol 
• 100928-08-3 de-A,B-25,25-(ethylenedioxy)-27-norcholestan-8β-ol 
• 100928-05-0 {(1R,3aR,4S,7aR)-octahydro-1-[(S)-1-iodopropan-2-yl]-7a-methyl-1H-inden-4-yloxy}(tert-butyl)dimethylsilane 
• 100928-04-9 (S)-2-((1R,3aR,4S,7aR)-4-((tert-butyldimethylsilyl)oxy)-7a-methyloctahydro-1H-inden-1-yl)propyl 4-methylbenzenesulfonate 

Downstream Products

• 140710-90-3 (R)-6-{(1R,3aS)-4-[2-[(S)-5-(tert-Butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(E)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-2-methyl-heptan-2-ol 
• 19356-17-3 (S)-3-[2-[(1R,3aS)-1-((R)-5-Hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-4-methylene-cyclohexanol 
• 32222-06-3 1α,25-dihydroxycholecalciferol 
• 132054-64-9 (1S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-[2-[(1R,3aS)-1-((R)-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-2-methylene-cyclohexanol 
• 132054-64-9 (1S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-[2-[(1R,3aS)-1-((R)-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-2-methylene-cyclohexanol 
• 99447-30-0 C₂₇H₄₄O₅S 

Relevant academic research and scientific papers

Stereoselective Palladium-Catalyzed Approach to Vitamin D3 Derivatives in Protic Medium

We describe an efficient convergent synthesis of vitamin D3 metabolites and analogues. The synthetic strategy relies on a tandem Pd-catalyzed A-ring closure and Suzuki–Miyaura coupling to the CD-side chain component to set directly the vitamin D triene system under protic conditions. This strategy enables rapid access to vitamin D3 and 3-epi-vitamin D3 metabolites and analogues modified at the side chain for biological evaluation and structural and metabolic studies.

Studies on the Synthesis of Side-Chain Hydroxylated Metabolites of Vitamin D. 3. Synthesis of 25-Ketovitamin D3 and 25-Hydroxyvitamin D3

A general method for the synthesis of the principal vitamin D3 metabolites whether unlabeled or with radiolabeled side chains is described.The synthesis of the key de-A,B-(ethylenedioxy)cholestanone derivative 7d is based on the coupling between the iodid