73811-76-4Relevant academic research and scientific papers
Ring-opening of 2,3-epoxy-1-propanol with R3Al: Unprecedented regiochemical switching simply achieved by changing alkyl substituents of aluminium reagent
Lewiński, Janusz,Horeglad, Pawe?,Tratkiewicz, Ewa,Justyniak, Iwona,Ochal, Zbigniew
, p. 3697 - 3699 (2007/10/03)
Several control experiments were designed to optimize the reaction of 2,3-epoxy-1-propanol with R3Al (R = Me, Et or iBu) and to probe for the nature of aluminium-bound alkyl groups that influence the reactivity and selectivity. The reported studies revealed that the Et 3Al mediated reaction leads to the C-2 product in contrast to the well-known C-3 substitution promoted by Me3Al.
