7383-74-6Relevant academic research and scientific papers
Cyclotrimerization of phenylacetylene catalyzed by a cobalt half-sandwich complex embedded in an engineered variant of transmembrane protein FhuA
Thiel,Sauer,Mertens,Polen,Chen,Schwaneberg,Okuda
supporting information, p. 5452 - 5456 (2018/08/12)
An (η5-cyclopentadienyl)cobalt(i) complex was covalently incorporated into an engineered variant of the transmembrane protein ferric hydroxamate uptake protein component: A, FhuA ΔCVFtev, using a thiol-ene reaction. A CD spectrum shows the structural integrity of the biohybrid catalyst. MALDI-TOF of the segment containing the anchoring site for the cobalt complex Cys545 confirmed successful conjugation. This biohybrid catalyst catalyzed the cyclotrimerization of phenylacetylene to give a mixture of regioisomeric 1,2,4- and 1,3,5-triphenylbenzene in aqueous medium.
PH Influenced molecular switching with micelle bound cavitands
Kim, Yeon Joo,Lek, Mark T.,Schramm, Michael P.
supporting information; experimental part, p. 9636 - 9638 (2011/10/05)
A series of resorcinarene host-amphiphilic guest complexes have been developed where guest orientation in the host is drastically influenced by pH. Guests appended with a trimethylammonium and a tert-butyl group switch orientation by 180° in response to a
Ditopic crown ether-guanidinium ion receptors for the molecular recognition of amino acids and small peptides
Sp?th, Andreas,K?nig, Burkhard
supporting information; experimental part, p. 1859 - 1873 (2010/04/06)
A series of ditopic synthetic receptors based on a crown ether-guanidinium ion recognition motif is reported. The compounds show binding affinity to selected amino acids, including important neurotransmitters. The effect of the distance of the ammonium and the carboxylate ion, the rigidity of the spacer, and the use of pre-organized pyrrole- and pyrene-guanidinium groups on binding affinity and selectivity are discussed.
A Microscopic Hydrophobicity Parameter
Menger, F. M.,Venkataram, U. V.
, p. 2980 - 2984 (2007/10/02)
p-Nitrophenyl laurate at 1x1E-5 M in water forms aggregates within which the ester groups hydrolyze slowly (about 1E3 less than a short-chain monomer).Salts of the general structure RNMe3+X- disrupt or destroy the aggregates; the ester groups are thereby "deshielded", and the observed hydrolysis rate increases.The magnitude of the rate increase at a given salt concentration depends on R: the more hydrophobic the R group, the greater the rate enhancement.This observation provided the basis of a "microscopic" hydrophobicity parameter MH which was evaluated for 25 different Rs (e.g., MH=0.73, 0.97, and 1.33 for R=ethyl, n-butyl, and n-hexyl).MH values were used to assess the role of branching, unsaturation, cyclization, aromaticity, halogenation, etc., in hydrophobic association.The parameters correlate well with Hansch ? values for aliphatic substituents but not for aromatic groups.Since the MH scale is based on the specific binding of one molecule to another, it may be well suited for modeling association among bioactive species.
