73847-52-6 Usage
Uses
Used in Pharmaceutical Industry:
1-(2-deoxypentofuranosyl)-5-(2-phenylethyl)pyrimidine-2,4(1H,3H)-dione is used as a pharmaceutical candidate for the development of antiviral and anticancer drugs due to its ability to inhibit DNA synthesis and interfere with the replication of viral and cancerous cells.
Used in Antiviral Applications:
In the field of antiviral research, 1-(2-deoxypentofuranosyl)-5-(2-phenylethyl)pyrimidine-2,4(1H,3H)-dione is used as an antiviral agent to target and inhibit the replication of various viruses, potentially leading to the development of new treatments for viral infections.
Used in Anticancer Applications:
1-(2-deoxypentofuranosyl)-5-(2-phenylethyl)pyrimidine-2,4(1H,3H)-dione is also used as an anticancer agent, where it may be employed to target and inhibit the replication of cancerous cells, contributing to the development of novel cancer therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 73847-52-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,3,8,4 and 7 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 73847-52:
(7*7)+(6*3)+(5*8)+(4*4)+(3*7)+(2*5)+(1*2)=156
156 % 10 = 6
So 73847-52-6 is a valid CAS Registry Number.
73847-52-6Relevant academic research and scientific papers
Independent Generation and Reactivity of 2′-Deoxy-5-methyleneuridin-5-yl, a Significant Reactive Intermediate Produced from Thymidine as a Result of Oxidative Stress
Anderson, Aaron S.,Hwang, Jae-Taeg,Greenberg, Marc M.
, p. 4648 - 4654 (2007/10/03)
2′-Deoxy-5-methyleneuridin-5-yl (1) is produced in a variety of DNA damage processes and is believed to result in the formation of lesions that are mutagenic and refractory to enzymatic repair. 2′-Deoxy-5-methyleneuridin-5-yl (1) was independently generated under anaerobic conditions via Norrish Type I photocleavage during Pyrex filtered photolysis of the benzyl ketone 7. The radical (1) exhibits behavior consistent with that of a resonance-stabilized radical. The KIE for hydrogen atom transfer from t-BuSH was found to be 7.3 ± 1.7. Competition studies between radical recombination and hydrogen atom donors (2,5-dimethyltetrahydrofuran, kTrap = 46.1 ± 15.4 M-1 s-1; propan-2-ol, kTrap = 13.6 ± 3.5 M-1 s-1) chosen to mimic the carbohydrate components of 2′-deoxyribonucleotides suggest that 2′-deoxy-5-methyleneuridin-5-yl (1) may be able to transfer damage from the nucleobase to the deoxyribose of an adjacent nucleotide in DNA under hypoxic conditions.
