738521-78-3

Basic information

• Product Name: 3-(benzyloxy)-6-methylpicolinic acid
• Synonyms: 3-(benzyloxy)-6-methylpicolinic acid
• CAS NO: 738521-78-3
• Molecular Formula: C14H13NO3
• Molecular Weight: 243.262
• Mol File: 738521-78-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-(benzyloxy)-6-methylpicolinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(benzyloxy)-6-methylpicolinic acid(738521-78-3)
• EPA Substance Registry System: 3-(benzyloxy)-6-methylpicolinic acid(738521-78-3)

Safety Data

• Hazardous Substances Data: 738521-78-3(Hazardous Substances Data)

Upstream product

• 30683-08-0 (3-benzyloxy-6-methyl-pyridin-2-yl)-methanol 
• 42097-42-7 3-hydroxy-2-hydroxymethyl-6-methylpyridine 
• 100-39-0 benzyl bromide 

Relevant articles and documents

4,4-DIFLUORO-PIPERIDINE-COMPOUNDS

The invention, in a first aspect relates to compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein R is a 6-membered aromatic ring, or a 5- or 6-membered heteroaromatic ring comprising 1 to 3 heteroatoms selected from S, O and N,

CHEMICAL COMPOUNDS

The invention relates to a novel compound of formula (I) or a stereoisomer, or a racemate or a mixture or a pharmaceutically acceptable salt thereof: wherein: R is phenyl or a 5- or 6-membered heteroaryl ring containing 1 to 3 heteroatoms selected from S, N and O, such rings may be optionally substituted with n groups Q; Q is selected from a group consisting of: C1-C4 alkyl, halogen, halo C1-C4 alkyl, C1-C4 alkoxy, CN, SO2CH3 or a group -O[(CR1R2]pQ1; or Q may be a group Q2; Q1 is phenyl, which may be optionally substituted with n substituents selected from a group consisting of: C1-C4 alkyl, halogen, halo C1-C4 alkyl, C1-C4 alkoxy, CN, or a group Q2; or corresponds to 2,2-difluoro- benzo[d][1,3]dioxol-4-yl; Q2 is a 5- or 6-membered heteroaryl containing at least one nitrogen atom, which may optionally substituted with n substituents selected from a group consisting of: C1 C1-C4 alkyl, halogen, halo C1-C4 alkyl, C1-C4 alkoxy, CN; P is a 6-membered heteroaryl or a 8-1 1 membered bicylic heteroaryl group, which may be substituted with n substituents selected from a group consisting of: C1-C4 alkyl, halogen, halo C1-C4 alkyl, C1-C4 alkoxy, CN; R1 is hydrogen or C1-C3 alkyl; R2 is hydrogen or C1-C3 alkyl; n is 1, 2 or 3; p is 0, 1 or 2; and with the proviso that when R corresponds to phenyl, P is substituted by at least one CF3; processes for the preparation of those compounds, pharmaceutical compositions containing one or more compounds of formula (I) and their use as dual antagonists of the Orexin 1 and Orexin 2 receptors.