738546-03-7

Basic information

• Product Name: 1-Piperidinepropanamide, N-(4-aminophenyl)-
• CAS NO: 738546-03-7
• Molecular Formula: C14H21N3O
• Molecular Weight: 247.34
• Mol File: 738546-03-7.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 1-Piperidinepropanamide, N-(4-aminophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinepropanamide, N-(4-aminophenyl)-(738546-03-7)
• EPA Substance Registry System: 1-Piperidinepropanamide, N-(4-aminophenyl)-(738546-03-7)

Safety Data

• Hazardous Substances Data: 738546-03-7(Hazardous Substances Data)

Usage

Chemical structure

Contains a piperidine ring and an acetyl group attached to a 4-aminophenyl moiety

Derivative

Of piperidine

Common uses

In the synthesis of pharmaceuticals and organic compounds, as an intermediate in the production of various drugs and related substances

Potential applications

In the development of new medications due to its pharmacological properties

Versatility

As a building block for the creation of biologically active molecules

Upstream product

• 90279-43-9 N-(4-nitro-phenyl)-3-(piperidin-1-yl)-propionamide 
• 110-89-4 piperidine 
• 19313-88-3 3-chloro-N-(4-nitrophenyl)propanamide 
• 100-01-6 4-nitro-aniline 

Downstream Products

• 1094648-01-7 1,3-bis(3-(1-(4-(3-(piperidin-1-yl)propanamido)phenyl)-1H-1,2,3-triazol-4-yl)phenyl)urea 
• 1191091-14-1 N₄,N₅-bis(4-(3-(piperidin-1-yl)propanamido)phenyl)-9,10-dihydro-9-oxoacridine-4,5-dicarboxamide 
• 1070978-56-1 1,3-bis(3-(4-(3-(piperidin-1-yl)propanamido)phenylcarbamoyl)phenyl)urea 
• 921201-91-4 N-(4-azido-phenyl)-3-(piperidin-1-yl)-propionamide 
• 1622093-60-0 N-(4-(4-((4-(1H-phenanthro[9,10-d]imidazol-2-yl)phenoxy)methyl)-1H-1,2,3-triazol-1-yl)phenyl)-3-(piperidin-1-yl)propanamide 
• 1446421-16-4 N-(4-(3-(4-(bis(2-chloroethyl)amino)phenyl)ureido)phenyl)-3-(piperidin-1-yl)propanamide 

Relevant articles and documents

Design and synthesis of potent antitumor water-soluble phenyl N-mustard-benzenealkylamide conjugates via a bioisostere approach

A series of new, water-soluble phenyl N-mustard-benzenealkylamide conjugates containing hydrophilic ω-dialkylaminoalkylamide or ω-cyclic aminoalkylamide moieties were synthesized via a bioisostere approach. These compounds have a broad spectrum of antitumor activity against a panel of human tumor cell lines. Of these derivatives, compound 18b effectively suppressed the growth of colon cancer (HCT-116), prostate cancer (PC3), and lung cancer (H460) xenografts. The growth of HCT-116 xenografts was almost completely suppressed when co-treated with compound 18b and 5-fluorouracil. Furthermore, compound 18b can induce DNA cross-linking and cell-cycle arrest at the G2/M phase. Early preclinical studies, including pharmacokinetics in rats, inhibition of the hERG, and 14 days of acute intravenous injection toxicity, suggest that compound 18b is a promising candidate for further preclinical studies.

Design, synthesis and evaluation of 4,5-di-substituted acridone ligands with high G-quadruplex affinity and selectivity, together with low toxicity to normal cells

A series of 4,5-di-substituted acridones have been designed and synthesized. Several compounds show high affinity for telomeric G-quadruplex DNA in classical and competition FRET assays, together with low duplex DNA affinity, although they do not show activity in a telomerase assay or evidence of telomere shortening. They have low toxicity against a panel of cancer cell lines and a normal human fibroblast line, and produce potent senescence-based long-term growth arrest in the MCF7 and A549 cancer cell lines.

UREYLENE DERIVATIVES

The invention concerns compounds of Formula (I) or a salt, solvate or pro-drug thereof. The compounds may be used in therapy, particularly anti-cancer therapy.