738606-64-9

Basic information

• Product Name: diethyl 8‐hydroxy‐2,2,14,14‐tetramethylpentadecanedioate
• Synonyms: diethyl 8‐hydroxy‐2,2,14,14‐tetramethylpentadecanedioate
• CAS NO: 738606-64-9
• Molecular Weight: 400.599
• Mol File: 738606-64-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: diethyl 8‐hydroxy‐2,2,14,14‐tetramethylpentadecanedioate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl 8‐hydroxy‐2,2,14,14‐tetramethylpentadecanedioate(738606-64-9)
• EPA Substance Registry System: diethyl 8‐hydroxy‐2,2,14,14‐tetramethylpentadecanedioate(738606-64-9)

Safety Data

• Hazardous Substances Data: 738606-64-9(Hazardous Substances Data)

Upstream product

• 738606-43-4 2,2,14,14-tetramethyl-8-oxopentadecanedioic acid diethyl ester 

Downstream Products

• 738606-46-7 ETC-1002 

Relevant articles and documents

Synthesis of bempedoic acid through electrochemical decarboxylation of dialkylated malonic acid

Bempedoic acid is a small-molecule inhibitor of adenosine triphosphate-citrate lyase (ACL) that is effective in the treatment of hypercholesterolemia and hypertension. In this paper, a new, six-step synthesis of bempedoic acid with 42% overall yield is reported. Ketone formation by electrochemical decarboxylation of dialkylated malonic acid is introduced as the key step of this process. This method uses mild conditions and its high efficiency makes it potentially suitable for industrial production.

PROCESS FOR PREPARATION OF BEMPEDOIC ACID

Aspect of the present application provides cost effective and commercially viable process for preparation of Bempedoic acid. The process involves the reduction of compound formula I to obtain compound formula II which is hydrolyzed to get Bempedoic acid. The present application also provides the process for preparation of Bempedoic acid using compound of formula II without purification.