738608-53-2Relevant academic research and scientific papers
Synthesis of substituted carbazoles and β-carbolines by cyclization of diketoindole derivatives
Duval, Eric,Cuny, Gregory D.
, p. 5411 - 5413 (2007/10/03)
A new route to substituted β-carbolines and carbazoles is described. Diketoindole intermediates, prepared by Friedel-Crafts acylations of 3-substituted indoles, have been converted to 3-hydroxycarbazoles and β-carbolines in good yields, 51-96% and 82-97%, respectively. This method also allows for the formation of 4-substituted β-carbolines. The application of this methodology to the synthesis of the natural products hyellazole and 6-chlorohyellazole is also described.
