738615-92-4

Upstream product

• 108-24-7 acetic anhydride 
• 104566-44-1 4-(1,3-dioxacyclopent-2-yl)benzylamine 
• 66739-89-7 4-(1,3-dioxolan-2-yl)benzonitrile 
• 105-07-7 4-cyanobenzaldehyde 
• 75-36-5 acetyl chloride 

Downstream Products

• 156866-50-1 N-[(4-formylphenyl)methyl]acetamide 
• 104566-44-1 4-(1,3-dioxacyclopent-2-yl)benzylamine 
• 845725-39-5 1-{4-[(acetylamino)methyl]benzyl}-N-cycloheptyl-2-(2-naphthylsulfonyl)-1-hydrazinecarboxamide 
• 845725-37-3 N-(4-{[1-(azepanylcarbonyl)-2-(2-naphthylsulfonyl)hydrazino]methyl}benzyl)acetamide 
• 845725-35-1 N-(4-{[1-[(2-methyl-1-piperidinyl)carbonyl]-2-(2-naphthylsulfonyl)hydrazino]methyl}benzyl)acetamide 
• 845725-36-2 N-(4-{[2-(2-naphthylsulfonyl)-1-(1-piperidinylcarbonyl)hydrazino]methyl}benzyl)acetamide 
• 738615-56-0 N-(4-{[1-[(4-methyl-1-piperidinyl)carbonyl]-2-(2-naphthylsulfonyl)hydrazino]methyl}benzyl)acetamide 
• 845725-38-4 1-{4-[(acetylamino)methyl]benzyl}-N-cyclopentyl-2-(2-naphthylsulfonyl)-1-hydrazinecarboxamide 

Relevant academic research and scientific papers

Cleavage of unactivated amide bonds by ammonium salt-accelerated hydrazinolysis

Hydrazinolysis of unactivated amide bonds is significantly accelerated by the addition of ammonium salts. The reactions proceed at 50-70 °C to give amines with broad substrate scope that outperforms existing amide bond cleavage reactions. Application to peptide and amino sugar derivatives is also demonstrated. This journal is

Novel non-covalent azaphenylalanine thrombin inhibitors with an aminomethyl or amino group at the P1 position

Design, synthesis and biological evaluation of a series of novel non-covalent azaphenylalanine thrombin inhibitors are presented. Replacement of the basic benzamidine moiety in azaphenylalanine derivatives by benzylamine (P1 part of a molecule) and the in