738626-27-2

Upstream product

• 51608-60-7 N-(benzylidene)-p-methylbenzenesulfonamide 
• 105123-35-1 2,4,6-tris([1,1'-biphenyl]-4-yl)boroxine 
• 100-52-7 benzaldehyde 
• 51608-60-7 phenyl N-tosyl imine 
• 5122-94-1 4-biphenylboronic acid 
• 738626-16-9 N-[2-(trimethylsilyl)benzylidene]-4-methylbenzenesulfonamide 
• 17887-55-7 2-trimethylsilylbenzaldehyde 
• 738626-26-1 (+)-N-{4-biphenyl-[2-(trimethylsilyl)phenyl]methyl}-4-methylbenzenesulfonamide 
• 70-55-3 toluene-4-sulfonamide 

Downstream Products

• 292066-56-9 (R)-(+)-α-(4-biphenylyl)benzylamine 

Relevant academic research and scientific papers

Exogenous-Base-Free Palladacycle-Catalyzed Highly Enantioselective Arylation of Imines with Arylboroxines

Enantiomerically pure benzylic amines are important for the development of new drugs. A readily accessible planar-chiral ferrocene-derived palladacycle is shown to be a highly efficient catalyst for the formation of N-substituted benzylic stereocenters; t

Enantioselective and rapid Rh-catalyzed arylation of N -tosyl- and N -nosylaldimines in methanol

Enantiomerically enriched tosyl-protected diarylmethylamines were rapidly prepared by the asymmetric addition of arylboronic acids to N-tosylaldimines under mild conditions in the presence of a catalyst prepared in situ from Rh(I) and a chiral diene ligand. This methodology offers access to diarylmethylamines in good yields with excellent chiral purity at room temperature using MeOH as a solvent and NEt3 as a base. Its synthetic utility was demonstrated by the preparation of (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline (14), an antagonist of the N-methyl-d-aspartate (NMDA) receptor.

Steric tuning of the amidomonophosphane-rhodium(l) catalyst in asymmetric addition of arylboroxines to n-phosphinoyl aldimines

Highly enantioselective rhodium-catalyzed addition of arylboroxlnes to N-phosphinoylaldimines was realized by the steric tuning of a dlphenylphosphorus moiety to a di(o-tolyl)phosphorus moiety of a chiral amidomonophosphane. The presence of MS 4 A in a 5:1 solvent mixture of dioxane-propanol was essential to afford the corresponding dlarylmethylamines In high yield.

N-Boc-L-valine-connected amidomonophosphane rhodium(I) catalyst for asymmetric arylation of N-tosylarylimines with arylboroxines

A catalytic asymmetric arylation of sterically tuned imines with arylboroxines was developed by using N-Boc-L-valine-connected amidomonophosphane rhodium(I) catalyst in n-PrOH. The TMS group used for the steric tuning of imines is convertible to other fun