73877-78-8Relevant articles and documents
Recyclization of 2-imino-2H-1-benzopyrans under the action of nucleophilic reagents. 5. Interaction of 2-iminocoumarin-3-carboxamide with anthranilic acid and its derivatives
Kovalenko,Bylov,Belokon',Chernykh
, p. 1026 - 1031 (2007/10/03)
N-Substituted 2-iminocoumarins are formed on reacting 2-iminocoumarin-3-carboxamide with anthranilic acid, methyl anthranilate, anthranilamide, and anthranilonotrile. Depending on the reaction conditions these recyclize into the corresponding 3-substituted coumarins or are hydrolyzed to coumarin-3- carboxamide. An alternative synthesis of some of the compounds has been effected.
Synthesis and anti-inflammatory activity of N-substituted 2-oxo-2H-1- benzopyran-3-carboxamides and their 2-iminoanalogues
Bylov, Igor E.,Vasylyev, Maksym V.,Bilokin, Yaroslav V.
, p. 997 - 1001 (2007/10/03)
A series of N-arylsubstituted 2-imino-2H-1-benzopyran-3-carboxamides 3a and b and 2-oxo-2H-1-benzopyran-3-carboxamides 4a-h were synthesized and evaluated for their anti-inflammatory activity in carrageenan-induced rat paw oedema assays and in acetic acid-induced peritonitis tests in albino rats. The resulting products were found to be active anti-inflammatory agents and their effects were comparable to that of piroxicam as the reference compound. In the consideration of the efficacy of the compounds in these assays, 2- imino/oxo-2H-1-benzopyran-3-carboxamides 3a and b and 4a-h were further studied at graded doses for their acute toxicity (ALD50) in albino mice and were essentially non-toxic at the highest dose tested.
