73877-78-8

Basic information

• Product Name: 2-{[(2-oxo-2H-chromen-3-yl)carbonyl]amino}benzoic acid
• Synonyms: 2-{[(2-oxo-2H-chromen-3-yl)carbonyl]amino}benzoic acid
• CAS NO: 73877-78-8
• Molecular Formula: C₁₇H₁₁NO₅
• Molecular Weight: 309.27294
• Mol File: 73877-78-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-{[(2-oxo-2H-chromen-3-yl)carbonyl]amino}benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{[(2-oxo-2H-chromen-3-yl)carbonyl]amino}benzoic acid(73877-78-8)
• EPA Substance Registry System: 2-{[(2-oxo-2H-chromen-3-yl)carbonyl]amino}benzoic acid(73877-78-8)

Safety Data

• Hazardous Substances Data: 73877-78-8(Hazardous Substances Data)

Upstream product

• 3757-06-0 coumarin 3-carboxylic acid chloride 
• 118-92-3 anthranilic acid 
• 52218-17-4 2-imino-2H-1-benzopyran-3-carboxamide 
• 212207-07-3 2-[(N-2-carboxyphenyl)imino]coumarin-3-carboxamide 
• 89-95-2 2-methyl-benzyl alcohol 
• 101646-18-8 2-carboxymalonanilic acid ethyl ester 

Relevant articles and documents

Recyclization of 2-imino-2H-1-benzopyrans under the action of nucleophilic reagents. 5. Interaction of 2-iminocoumarin-3-carboxamide with anthranilic acid and its derivatives

N-Substituted 2-iminocoumarins are formed on reacting 2-iminocoumarin-3-carboxamide with anthranilic acid, methyl anthranilate, anthranilamide, and anthranilonotrile. Depending on the reaction conditions these recyclize into the corresponding 3-substituted coumarins or are hydrolyzed to coumarin-3- carboxamide. An alternative synthesis of some of the compounds has been effected.

A new pathway to 3-hetaryl-2-oxo-2H-chromenes: On the proposed mechanisms for the reaction of 3-carbamoyl-2-iminochromenes with dinucleophiles

The present account summarizes the author's studies to elucidate the mechanisms of the recently reported rearrangements resulting from inter- and/or intramolecular reactions of 2-imino-2H-chromene-3-carboxamides with different dinucleophiles.

Synthesis and anti-inflammatory activity of N-substituted 2-oxo-2H-1- benzopyran-3-carboxamides and their 2-iminoanalogues

A series of N-arylsubstituted 2-imino-2H-1-benzopyran-3-carboxamides 3a and b and 2-oxo-2H-1-benzopyran-3-carboxamides 4a-h were synthesized and evaluated for their anti-inflammatory activity in carrageenan-induced rat paw oedema assays and in acetic acid-induced peritonitis tests in albino rats. The resulting products were found to be active anti-inflammatory agents and their effects were comparable to that of piroxicam as the reference compound. In the consideration of the efficacy of the compounds in these assays, 2- imino/oxo-2H-1-benzopyran-3-carboxamides 3a and b and 4a-h were further studied at graded doses for their acute toxicity (ALD50) in albino mice and were essentially non-toxic at the highest dose tested.