73913-65-2

Basic information

• Product Name: H-D-LEU-OET HCL
• Synonyms: D-LEUCINE ETHYL ESTER HCL;D-LEUCINE ETHYL ESTER HYDROCHLORIDE;H-D-LEU-OET HCL;H-D-Leu-OEt·HCl D-Leucine ethyl ester hydrochloride;Ethyl D-leucinate hydrochloride;(R)-Ethyl 2-aMino-4-Methylpentanoate hydrochloride;NSC 45692;(R)-2-amino-4-methyl-pentanoic acid ethyl ester hydrochloride
• CAS NO: 73913-65-2
• Molecular Formula: C₈H₁₇NO₂*ClH
• Molecular Weight: 195.69
• Product Categories: Amino hydrochloride
• Mol File: 73913-65-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 121-127℃
• Boiling Point: 191.4 °C at 760 mmHg
• Flash Point: 62.9 °C
• Appearance: White/Powder
• Vapor Pressure: 0.515mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• Sensitive: Hygroscopic
• CAS DataBase Reference: H-D-LEU-OET HCL(CAS DataBase Reference)
• NIST Chemistry Reference: H-D-LEU-OET HCL(73913-65-2)
• EPA Substance Registry System: H-D-LEU-OET HCL(73913-65-2)

Safety Data

• Hazardous Substances Data: 73913-65-2(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

H-D-Leu-oet hcl

InChI:InChI=1/C8H17NO2.ClH/c1-4-11-8(10)7(9)5-6(2)3;/h6-7H,4-5,9H2,1-3H3;1H/t7-;/m1./s1

Upstream product

• 64-17-5 ethanol 
• 328-39-2 LEUCINE 
• 82636-80-4 PChd-LeuLOEt 

Downstream Products

• 39978-35-3 rac-N-benzyloxycarbonyl-leucine ethyl ester 
• 211997-18-1 C₂₁H₂₅NO₂ 
• 510714-32-6 (2S)-4-methyl-2-{[(3R)-4-(toluene-4-sulfonyl)thiomorpholine-3-carbonyl]amino}pentanoic acid ethyl ester 

Relevant articles and documents

Enantioselective synthesis of α-secondary and α-tertiary piperazin-2- Ones and piperazines by catalytic asymmetric allylic alkylation

The asymmetric palladium-catalyzed decarboxylative allylic alkylation of differentially N-protected piperazin-2- ones allows the synthesis of a variety of highly enantioenriched tertiary piperazine-2-ones. Deprotection and reduction affords the corresponding tertiary piperazines, which can be employed for the synthesis of medicinally important analogues. The introduction of these chiral tertiary piperazines resulted in imatinib analogues which exhibited comparable antiproliferative activity to that of their corresponding imatinib counterparts.

Anthranilic acid based CCK1 receptor antagonists: Blocking the receptor with the same 'words' of the endogenous ligand

The anthranilic acid diamides represent the more recent class of nonpeptide CCK1 receptor antagonists. This class is characterized by the presence of anthranilic acid, used as a molecular scaffold, and two pharmacophores selected from the C-terminal tetrapeptide of CCK. The lead compound coded VL-0395, endowed with sub-micromolar affinity towards CCK1 receptors, was characterized by the presence of Phe and 2-indole moiety at the C- and N-termini of anthranilic acid, respectively. Herein we describe the first step of the anthranilic acid C-terminal optimization using, instead of Phe, aminoacids belonging to the primary structure of CCK-8 and other not coded residues. Thus we demonstrate that the CCK1 receptor affinity depends on the nature of the aminoacidic side chain as well as that the free carboxy group of the alpha-aminoacids is crucial for the binding. The R enantiomers of the most active compounds represent the eutomers of this class of antagonists confirming thus the stereo preference of the receptor. Moreover this SAR study demonstrates that the receptor binding pocket, that host the aminoacidic side chain, results much more tolerant respect to that accommodating the indole ring. As a result, an appropriate variation of the aminoacidic side chain could provide a better CCK1 receptor affinity diorthosis.

CLEAVAGE OF THE N-PChd GROUP FROM PROTECTED AMINO ACIDS AND PEPTIDES BY CATHODIC REDUCTION

Amino acids and peptide esters protected by the PChd group can be deprotected cathodically under mild conditions.