73918-57-7

Usage

Uses

Used in Pharmaceutical Synthesis:
2-(4-Iodophenyl)ethylamine is used as a key intermediate in the synthesis of various pharmaceuticals for its unique structural and chemical properties. It contributes to the development of new drugs by providing a versatile building block in medicinal chemistry.
Used in Research Chemicals:
In the field of research, 2-(4-Iodophenyl)ethylamine is used as a research chemical to explore its potential applications and properties. It aids scientists in understanding its interactions with biological systems and its role in chemical reactions.
Used in Medicinal Chemistry:
2-(4-Iodophenyl)ethylamine is employed as a component in medicinal chemistry for its distinctive properties, which can be leveraged to develop new therapeutic agents. Its structure allows for the creation of compounds with specific biological activities.
Used in Environmental and Safety Considerations:
Due to its potential toxicity and environmental impact, 2-(4-Iodophenyl)ethylamine is used as a case study for the development of proper handling and disposal procedures. This ensures that its use in laboratories and industrial settings is conducted safely and with minimal environmental harm.

Upstream product

• 1798-06-7 (4-iodophenyl)acetic acid 
• 52914-23-5 4-iodophenethyl alcohol 
• 874202-06-9 2-[2-(4-iodophenyl)ethyl]-1H-isoindole-1,3(2H)-dione 
• 51628-12-7 4-iodophenylacetonitrile 

Downstream Products

• 923284-26-8 2-(4-iodophenyl)-N,N-bis[2-(2-thienyl)ethyl]ethylamine 
• 923284-27-9 2-(4-iodophenyl)-N,N-bis(2-phenylethyl)ethylamine 
• 1177258-45-5 C₂₆H₄₀INO 
• 1177258-46-6 C₂₈H₄₀INO 
• 1333307-94-0 C₅₆H₉₅NO₄Si 
• 1333307-95-1 C₅₃H₈₇NO₄ 
• 1333307-93-9 C₅₁H₈₆INO₄ 
• 66491-04-1 7-iodo-3,4-dihydro-1(1H)-isoquinolinone 

Relevant academic research and scientific papers

Electric-field-responsive handle for large-area orientation of discotic liquid-crystalline molecules in millimeter-thick films

Current events: An electric-field-responsive handle (see picture) was developed that enables large-area and millimeter-thick unidirectional orientation of columnarly assembled π-conjugated liquid-crystalline molecules. The handles in the columns are hydrogen-bonded and align along the direction of an applied electric field.

Synthesis, in vitro and in vivo evaluation, and radiolabeling of aryl anandamide analogues as candidate radioligands for in vivo imaging of fatty acid amide hydrolase in the brain

Fatty acid amide hydrolyase (FAAH) is one of the main enzymes responsible for terminating the signaling of endocannabinoids in the brain. Imaging FAAH in vivo using PET or SPECT is important to deeper understanding of its role in neuropsychiatric disorders. However, at present, no radioligand is available for mapping the enzyme in vivo. Here, we synthesized 18 aryl analogues of anandamide, FAAH's endogenous substrate, and in vitro evaluated their potential as metabolic trapping tracers. Interaction studies with recombinant FAAH revealed good to very good interaction of the methoxy substituted aryl anandamide analogues 17, 18, 19, and 20 with FAAH and they were identified as competing substrates. Compounds 17 and 18 did not display significant binding to CB1 and CB2 cannabinoid receptors and stand out as potential candidate metabolic trapping tracers. They were successfully labeled with 11C in good yields and high radiochemical purity and displayed brain uptake in C57BL/6J mice. Radioligands [11C]-17 and [ 11C]-18 merit further investigation in vivo.

Aryl aniline beta2 adrenergic receptor agonists

The invention provides novel β2 adrenergic receptor agonist compounds of formula (I): wherein R1-R13 and w have any of the values described in the specification. The invention also provides combinations of such compounds and other therapeutic agents, pharmaceutical compositions comprising such compounds and combinations, methods of using such compounds to treat diseases associated with β2 adrenergic receptor activity, and processes and intermediates useful for preparing such compounds.