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Usage

Uses

Used in Pharmaceutical Industry:
1-(4-methoxyphenyl)-3-methylidenepyrrolidine-2,5-dione is used as a potential active pharmaceutical ingredient for the development of new drugs. Its structural features may allow it to target specific biological pathways or receptors, making it a candidate for the treatment of various diseases or conditions.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 1-(4-methoxyphenyl)-3-methylidenepyrrolidine-2,5-dione is used as a compound for further research and investigation. Its unique structure may provide insights into new drug design strategies and help in the development of more effective therapeutic agents.
Further research and investigation into the properties and potential uses of 1-(4-methoxyphenyl)-3-methylidenepyrrolidine-2,5-dione are necessary to fully understand its potential and unlock its applications in various industries.

Upstream product

• 2170-03-8 itaconic acid anhydride 
• 74448-29-6 N-<4-Methoxy-phenyl>-2-methylen-succinamidsaeure 
• 104-94-9 4-methoxy-aniline 

Downstream Products

• 1234887-96-7 3-(tert-butylthiomethyl)-1-(4-methoxyphenyl)pyrrolidine-2,5-dione 
• 1392115-13-7 (S)-(+)-methyl 2-((1-(4-methoxyphenyl)-4-methyl-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)(phenyl)methyl)acrylate 

Relevant academic research and scientific papers

N-Aryl-3-mercaptosuccinimides as Antivirulence Agents Targeting Pseudomonas aeruginosa Elastase and Clostridium Collagenases

In light of the global antimicrobial-resistance crisis, there is an urgent need for novel bacterial targets and antibiotics with novel modes of action. It has been shown that Pseudomonas aeruginosa elastase (LasB) and Clostridium histolyticum (Hathewaya histolytica) collagenase (ColH) play a significant role in the infection process and thereby represent promising antivirulence targets. Here, we report novel N-Aryl-3-mercaptosuccinimide inhibitors that target both LasB and ColH, displaying potent activities in vitro and high selectivity for the bacterial over human metalloproteases. Additionally, the inhibitors demonstrate no signs of cytotoxicity against selected human cell lines and in a zebrafish embryo toxicity model. Furthermore, the most active ColH inhibitor shows a significant reduction of collagen degradation in an ex vivo pig-skin model.

A highly efficient and stereoselective cycloaddition of nitrones to N-arylitaconimides

The 1,3-dipolar cycloaddition of keto- and aldonitrones with N-arylitaconimides proceeds regioselectively giving only 5-spiroisoxazolidines. In the case of aldonitrones the reaction proceeds with high diastereoselectivity. A range of the obtained adducts

Synthesis of cyclic imides (methylphtalimides, carboxylic acid phtalimides and itaconimides) and evaluation of their antifungal potential

Background: This paper describes the synthesis of three different subfamilies of cyclic imides: methylphtalimides, carboxyl acid phtalimides and itaconimides. Methods: Fifteen compounds (five of each sub-family) were obtained by the reaction of appropriat