7394-63-0

Usage

Chemical Class

Indole derivatives

Structure

Heterocyclic aromatic compound with a five-membered ring fused to a six-membered ring

Pharmaceutical Applications

Neuroprotective and anti-inflammatory properties, potential drug candidate for neurological disorders

Synthesis

Potential building block for the synthesis of other pharmaceutical compounds.

Upstream product

• 120-72-9 indole 
• 106-96-7 propargyl bromide 

Downstream Products

• 97311-31-4 1-phenyl-5-(3-indolyl)-1,3-pentadiyne 
• 2731-96-6 1,5-dihydrobenzindol-4(3H)-one 
• 150670-63-6 1,2,3,4-tetrahydro-cyclopentindol-2-one 

Relevant academic research and scientific papers

Indole-triazole conjugates are selective inhibitors and inducers of bacterial biofilms

Herein is described a method of accessing indole-triazole and benzothiophene-triazole analogues that selectively promote or inhibit biofilm formation by Gram-positive and Gram-negative bacteria. Structure/function studies revealed that the addition of a b

Enantioselective rhodium-catalyzed [4+2+2] cycloaddition of dienyl isocyanates for the synthesis of bicyclic azocine rings

(Chemical Equation Presented) A highly enantioselective rhodium-catalyzed [4+2+2] cycloaddition of terminal alkynes and dienyl isocyanates has been developed. The cycloaddition provides a rapid entry to highly functionalized and enantioenriched bicyclic a

Novel gallium-mediated C3-allylation of indoles and pyrroles in aqueous media promoted by Bu4NBr

A mild and efficient protocol for the coupling of indoles and pyrroles with allyl halides such as allyl bromide, crotyl bromide and propargyl bromide in the presence of gallium metal in a Bu4NBr-DMF-H2O system has been developed. The reaction is equally effective when cadmium is used in lieu of gallium and the corresponding 3-allyl indoles and 3-allyl pyrroles were obtained in almost comparable yields.

OXIDATIVE REACTIONS OF 3-PROPARGYLINDOLE

The respective biacetylenes were obtained by the oxidative condensation of 3-propargylindole with phenylacetylene and various acetylenic carbinols. 1-Phenyl-5-(3-indolyl)-1,3-pentadiyne was also obtained alternatively by the reaction of 3-propargylindole with phenylbromoacetylene by the Cadiot-Chodkiewicz reaction. 1-Bromo-3-(5-bromoindolyl)propyne and 1-bromo-3-(5,7-dibromoindolyl)propyne were synthesized by the bromination of 3-propargylindole.