73959-39-4

Basic information

• Product Name: Cyclohexanone, 3-(2-methylpropyl)-, (3R)-
• CAS NO: 73959-39-4
• Molecular Formula: C10H18O
• Molecular Weight: 154.252
• Mol File: 73959-39-4.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Cyclohexanone, 3-(2-methylpropyl)-, (3R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanone, 3-(2-methylpropyl)-, (3R)-(73959-39-4)
• EPA Substance Registry System: Cyclohexanone, 3-(2-methylpropyl)-, (3R)-(73959-39-4)

Safety Data

• Hazardous Substances Data: 73959-39-4(Hazardous Substances Data)

Upstream product

• 930-68-7 cyclohexenone 
• 926-62-5 isobutylmagnesium bromide 
• 6301-50-4 3-isobutylcyclohex-2-en-1-one 
• 1854-19-9 diisobutylzinc 
• 5674-02-2 2-methylpropylmagnesium chloride 
• 5674-05-5 5-isobutylcyclohexanone 
• 1728-18-3 dimethylacetal of cyclohexenone 

Downstream Products

• 87759-37-3 (1S,3R)-cis-3-isobutylcyclohexanol 
• 69854-67-7 (1R,3R)-trans-3-isobutlcyclohexanol 
• 87759-36-2 (1R,3S)-cis-3-isobutylcyclohexanol 

Relevant articles and documents

Counterion Enhanced Organocatalysis: A Novel Approach for the Asymmetric Transfer Hydrogenation of Enones

We present a novel strategy for organocatalytic transfer hydrogenations relying on an ion-paired catalyst of natural l-amino acids as main source of chirality in combination with racemic, atropisomeric phosphoric acids as counteranion. The combination of a chiral cation with a structurally flexible anion resulted in a novel chiral framework for asymmetric transfer hydrogenations with enhanced selectivity through synergistic effects. The optimized catalytic system, in combination with a Hantzsch ester as hydrogen source for biomimetic transfer hydrogenation, enabled high enantioselectivity and excellent yields for a series of α,β-unsaturated cyclohexenones under mild conditions. Moreover, owing to the use of readily available and chiral pool-derived building blocks, it could be prepared in a straightforward and significantly cheaper way compared to the current state of the art.

Copper-catalyzed asymmetric conjugate addition with Grignard reagents and SimplePhos ligands

Herein we report the copper-catalyzed asymmetric conjugate addition of Grignard reagents to cyclic and acyclic enones, with SimplePhos as chiral ligands. A variety of Grignard reagents can be added to a range of cyclic and acyclic enones, with moderate to good enantioselectivities (ee's up to 86%).

General method for the expedient synthesis of salt-free diorganozinc reagents using zinc methoxide

The effect of counterions has a great impact on the solubility of magnesium salts in Et2O. By reacting Zn(OMe)2 with readily available Grignard reagents, it was possible to induce the complete precipitation of magnesium salts and then obtain salt-free dio