7396-80-7

Upstream product

• 151-10-0 1,3-Dimethoxybenzene 
• 445-29-4 o-fluoro-benzoic acid 
• 138109-49-6 2,4-dimethoxyphenylmagnesium bromide 
• 393-52-2 2-Fluorobenzoyl chloride 

Downstream Products

• 3119-88-8 2'-fluoro-2-hydroxy-4-methoxybenzophenone 
• 906876-74-2 N₁-phenylmethyl-5-(1,2-benzisoxazol-3-yl)-2,4-dimethoxybenzenecarboxamide 
• 906876-62-8 5-(1,2-benzisoxazol-3-yl)-2,4-dimethoxybenzenecarboxylic acid 
• 906876-38-8 5-(1,2-benzisoxazol-3-yl)-2,4-dimethoxybenzenecarboxylic acid methyl ester 
• 1279869-86-1 5-(1,2-benzoxazol-3-yl)-2,4-dimethoxybenzaldehyde 
• 906876-03-7 3-(2,4-dimethoxyphenyl)-1,2-benzisoxazole 
• 1374822-45-3 (2,4-dimethoxyphenyl)(2-morpholinophenyl)methanone 
• 906875-92-1 (2,4-dimethoxyphenyl)-{2-[(isopropylidene)amino]oxyphenyl}methanone 

Relevant academic research and scientific papers

Continuous flow synthesis of diaryl ketones by coupling of aryl Grignard reagents with acyl chlorides under mild conditions in the ecofriendly solvent 2-methyltetrahydrofuran

An efficient continuous flow sequential synthesis of diaryl ketones was achieved by coupling of aryl Grignard reagents with acyl chlorides in the bio-derived “green” solvent 2-methyltetrahydrofuran (2-MeTHF) under mild reaction conditions (ambient temperature, 1 hour), allowing a safe and on-demand generation of 2-(3-benzoylphenyl)propionitrile with a productivity of 3.16 g hour?1

Method of utilizing continuous flow microreactor to synthesize benzophenone derivative

The invention belongs to the technical field of organic synthesis, and particularly relates to a method of utilizing a continuous flow microreactor to synthesize a benzophenone derivative. The methodincludes: using aryl Grignard reagent and acyl chloride as raw materials; at normal temperature, continuously synthesizing the benzophenone derivative in the microreactor; recycling a reaction solvent2-methyl tetrahydrofuran. Problems of environmental pollution and reaction operation safety caused by the fact that conventional Fridel-Crafts reaction is excessively dependent on reagents like aluminum trichloride, ferric trichloride and zinc dichloride are avoided, the defect that novel catalytic processes are expensive in catalytic reagent and harsh in operation condition is made up, and continuous synthesis of a medical intermediate ketoprofen nitrile is realized efficiently. The method has the advantages of high operation convenience, high reaction safety, high yield, high efficiency andreaction solvent reusability and is environment-friendly and efficient.

BeCl2 as a new highly selective reagent for dealkylation of aryl-methyl ethers

An efficient and simple method is introduced for the selective removal of methyl group from poly aryl-methyl ethers, in some important derivatives of benzophenones, xanthones, anthraquinones, aryl esters, benzamides and nitroanisoles with BeCl2.