7396-92-1

Basic information

• Product Name: 3,5-DICHLORO-2-HYDROXYBENZOPHENONE
• Synonyms: 3,5-DICHLORO-2-HYDROXYBENZOPHENONE
• CAS NO: 7396-92-1
• Molecular Formula: C₁₃H₈Cl₂O₂
• Molecular Weight: 267.11
• Mol File: 7396-92-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 115°C
• Boiling Point: 376.5 °C at 760 mmHg
• Flash Point: 181.5 °C
• Appearance: /
• Density: 1.406 g/cm³
• Vapor Pressure: 3.34E-06mmHg at 25°C
• Refractive Index: 1.631
• CAS DataBase Reference: 3,5-DICHLORO-2-HYDROXYBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-DICHLORO-2-HYDROXYBENZOPHENONE(7396-92-1)
• EPA Substance Registry System: 3,5-DICHLORO-2-HYDROXYBENZOPHENONE(7396-92-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-53-36/38
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 7396-92-1(Hazardous Substances Data)

Usage

Preparation

Preparation by adding aluminium chloride into a solution of 3,5-dichloro-2-hydroxybenzoyl chloride in benzene and heating at 60° for 3–4 h (60–70%).

InChI:InChI=1/C13H8Cl2O2/c14-9-6-10(13(17)11(15)7-9)12(16)8-4-2-1-3-5-8/h1-7,17H

Upstream product

• 71-43-2 benzene 
• 98-80-6 phenylboronic acid 
• 90-60-8 3,5-dichlorosalicyclaldehyde 
• 98-88-4 benzoyl chloride 
• 120-83-2 2,4-dichlorophenol 

Downstream Products

• 35503-82-3 3,5-dichloro-2-hydroxy-benzhydrol 
• 78224-95-0 6,8-Dichloro-4-phenyl-benzo[e][1,2,3]oxathiazine 2,2-dioxide 

Relevant articles and documents

Aerobic Copper-Catalyzed Salicylaldehydic Cformyl?H Arylations with Arylboronic Acids

We report a challenging copper-catalyzed Cformyl?H arylation of salicylaldehydes with arylboronic acids that involves unique salicylaldehydic copper species that differ from reported salicylaldehydic rhodacycles and palladacycles. This protocol has high chemoselectivity for the Cformyl?H bond compared to the phenolic O?H bond involving copper catalysis under high reaction temperatures. This approach is compatible with a wide range of salicylaldehyde and arylboronic acid substrates, including estrone and carbazole derivatives, which leads to the corresponding arylation products. Mechanistic studies show that the 2-hydroxy group of the salicylaldehyde substrate triggers the formation of salicylaldehydic copper complexes through a CuI/CuII/CuIII catalytic cycle.

Selective regeneration of carbonyl compounds from aldoximes and ketoximes, catalyzed by FeCl3 and SeO2

An oxidative deblocking procedure of aldoximes using FeCl3 and ketoximes using SeO2 in aprotic solvent is reported. Reaction yields are competitive as compared to previous methods. Reactions are easy to work and conditions are mild. Some important features of FeCl3 are mentioned.