73968-83-9

Upstream product

• 108-05-4 vinyl acetate 
• 75527-84-3 diphenylmethyl 6,6-dibromopenicillanate 
• 75527-85-4 benzhydryl 6β-bromopenicillanate 
• 74189-25-6 diphenylmethyl 6α-bromopenicillanate 
• 107-13-1 acrylonitrile 
• 24158-88-1 6,6-dibromopenicillanic acid 
• 908093-98-1 diazodiphenylmethane 
• 24138-28-1 6-bromopenicillanic acid 
• 303730-77-0 diphenylmethyl (2S)-2-[(4S)-4-chloro-2-oxazetidin-1-yl]-2-(1-chlorothio-1-methylethyl)-acetate 
• 292638-85-8 acrylic acid methyl ester 
• 76517-35-6 6,6-diiodopenicillanic acid benzhydryl ester 

Downstream Products

• 89789-07-1 (2S,3S,5R) 3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-yl-methyl)-4-thia-1-azabicyclo[3.2.0]heptane2-carboxylic acid 4,4-dioxide, diphenyl methyl ester 
• 85573-73-5 2β-(chloro)methyl-2α-methyl-6,6-dihydropenam-3α-carboxylic acid benzhydryl ester 
• 89786-04-9 tazobactam acid 
• 303730-77-0 diphenylmethyl (2S)-2-[(4S)-4-chloro-2-oxazetidin-1-yl]-2-(1-chlorothio-1-methylethyl)-acetate 

Relevant academic research and scientific papers

Syntheses of (6S)-cephalosporins from 6-aminopenicillanic acid

Two practical routes to (6S,7S)-cephalosporins from 6-aminopenicillanic acid (6-APA) are described. In the first, 6-APA was converted to (2S,4S,5S,6S)-penicillin sulfoxide 49, which underwent Morin ring expansion to a protected (6S,7S)-cephem 50. In the s

Isonitrile-nitrile rearrangement promoted by samarium(II) iodide

A samarium(II) iodide-promoted rearrangement of isonitriles to nitriles, which requires an α-alkoxycarbonyl group at the carbon atom bearing the isonitrile group, occurs under very mild conditions and contrasts with the thermal version of the rearrangement, which usually requires high temperature.

STEREOSELECTIVE SYNTHESIS OF 6α-HALOPENICILLANATES BY SAMARIUM(II) IODIDE PROMOTED REDUCTION OF 6,6-DIHALOPENICILLANATES

A mild an efficient samarium(II) iodide promoted-reduction of 6,6-dibromopenicillanates for stereoselective synthesis of 6α-bromopenicillanates has been developed.