73971-97-8Relevant academic research and scientific papers
Improved protocol for indoline synthesis via palladium-catalyzed intramolecular C(sp2)-H amination
He, Gang,Lu, Chengxi,Zhao, Yingsheng,Nack, William A.,Chen, Gong
, p. 2944 - 2947 (2012/08/28)
An efficient method has been developed for the synthesis of indoline compounds from picolinamide (PA)-protected β-arylethylamine substrates via palladium-catalyzed intramolecular amination of ortho-C(sp2)-H bonds. These reactions feature high efficiency, low catalyst loadings, mild operating conditions, and the use of inexpensive reagents.
Biogenesis of Epidithiadiketopiperazines. Synthesis of Three Isomeric (β-Aminoethyl)benzene Oxides
Rastetter, William H.,Nummy, Larry J.
, p. 3149 - 3155 (2007/10/02)
Three isomeric amine-substituted arene oxides have been synthesized to serve as models for the postulated involvement of amino acid derived arene oxides during the biosyntheses of various epidithiadiketopiperazines.No biogenetic-type reactivity was noted for the arene oxides.In all three cases aromatization rather than amine/epoxide cyclization was observed.The failure to duplicate the presumed in vivo reactivity of aminoarene oxides is discussed in terms of possible enzyme-mediated cyclizations in the natural systems.
