73984-05-1Relevant articles and documents
Gel phase synthesis of an octapeptide, H-Lys-Gly-Asp-Glu-Glu-Ser-Leu-Ala-OH on a flexible triethyleneglycol dimethacrylate-crosslinked polystyrene support
Chandy, Mathew C.,Pillai, V.N. Rajasekharan
, p. 303 - 307 (2007/10/03)
An octapeptide, H-Lys-Gly-Asp-Glu-Glu-Ser-Leu-Ala-OH corresponding to the sequence of the delicious peptide1 has been synthesised on a 2% triethyleneglycol dimethacylate-crosslinked polystyrene support (PS-TEGDMA). The new flexible polyoxyethylene crosslinked support is prepared from the styrene and TEGDMA by radical-induced suspension polymerisation. The functionalised support containing 1.74 mmole of chlorine/g has been used for the stepwise assembly of the peptide. Couplings of Boc-amino acids proceed smoothly in two stages. The peptide resin is finally cleaved to obtain the free peptide. The optimum hydrophilic-hydrophobic balance achieved in the solid support permit the synthetic manipulations to be carried in the gel phase. The synthesis illustrates the application of the novel flexible support in solid phase peptide synthesis.
The Relationship between Taste and Primary Structure of "Delicious Peptide" (Lys-Gly-Asp-Glu-Glu-Ser-Leu-Ala) from Beef Soup
Tamura, Masahiro,Nakatsuka, Tohru,Tada, Makoto,Kawasaki, Yoshihiro,Kikuchi, Eiichi,Okai, Hideo
, p. 319 - 326 (2007/10/02)
"Delicious peptide" was reported to be as delicious as beef soup.The peptide and its fragments were synthesized to study its taste active sites. "Delicious peptide" was found to produce a umami and a sour taste.By preparing several di- or tripeptides composed of basic or acidic amino acids, we found that the taste of "delicious peptide" was produced by an interaction between the basic and the acidic fragments in the peptide.