7399-69-1

Usage

Uses

Used in Pharmaceutical Industry:
N-(2-Hydroxyethyl)-3-nitrobenzaMide is utilized as a building block for the production of pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, contributing to the advancement of medicine.
Used in Chemical Industry:
In the chemical industry, N-(2-Hydroxyethyl)-3-nitrobenzaMide serves as a crucial intermediate for the synthesis of dyes and other organic compounds. Its ability to be functionalized makes it a valuable asset in creating a diverse range of products.
Used as a Precursor in Organic Synthesis:
N-(2-Hydroxyethyl)-3-nitrobenzaMide is recognized for its potential as a precursor in the synthesis of other functionalized nitrobenzamides. This role highlights its importance in expanding the scope of organic chemistry and the creation of novel compounds.

InChI:InChI=1/C9H10N2O4/c12-5-4-10-9(13)7-2-1-3-8(6-7)11(14)15/h1-3,6,12H,4-5H2,(H,10,13)

Upstream product

• 1517-05-1 2-azidoethanol 
• 7664-93-9 sulfuric acid 
• 99-61-6 3-nitro-benzaldehyde 
• 618-95-1 methyl 3-nitrobenzoate 
• 141-43-5 ethanolamine 
• 121-92-6 3-nitrobenzoic acid 
• 121-90-4 m-nitrobenzoic acid chloride 
• 618-98-4 ethyl 3-nitrobenzoate 

Downstream Products

• 103956-05-4 N-(2-Hydroxyethyl)-3-aminobenzamide 
• 88186-35-0 4,5-dihydro-2-(3-nitrophenyl)oxazole 
• 1240716-12-4 C₁₆H₁₅N₃O₃ 
• 1240716-13-5 C₁₆H₁₅N₃O₂ 
• 860682-01-5 3-nitro-benzoic acid-(2-chloro-ethylamide) 
• 1431843-51-4 C₃₃H₂₉N₄O₃⁽¹⁺⁾*Cl^(1-) 
• 1431843-50-3 3-(2-chloroacetamido)-N-(2-hydroxyethyl)benzamide 

Relevant academic research and scientific papers

Benzimidazolium-based receptors: Case of iodide-water cluster induced supramolecular chain and improved fluorometric binding of iodide involving alcoholic group

Benzimidazolium-based receptors 1 and 2 have been designed and synthesized. Anion binding studies reveal their selective fluorescence sensing of iodide in the excited state by exhibiting greater quenching of emission of anthracene. In the ground state, they prefer to bind bromide ion. Incorporation of alcoholic -OH in 2 leads to better performance over the receptor 1. The cyclooctameric structure as constituted by inclusion water and iodide interaction leads to ID-supramolecular chain with the structure 1 in the solid state. 1H NMR, UV-vis and fluorescence spectroscopic methods were adopted to study the anion binding behavior.

Cyclopalladated complexes of 2-(m-nitrophenyl)imidazolines: Synthesis, characterization and catalytic activity in the Suzuki reaction under mild conditions

Three cyclopalladated complexes of 2-(m-nitro-phenyl)imidazolines have been easily prepared and characterized by spectroscopic analysis. The structure of one of the complexes has been determined by single-crystal X-ray analysis. The complexes are effective catalysts for the Suzuki reaction of aryl bromides with phenylboronic acid in aqueous solution at room temperature under air. Springer Science+Business Media B.V. 2010.

2-Benzamidoethyl group - A novel type of phosphate protecting group for oligonucleotide synthesis

A number of 5′-O-(4,4′-dimethoxytrityl)thymidine N,N-diisopropylamino phosphoramidites protected at P(III) with derivatives of 2-benzamidoethanol were synthesized and incorporated into synthetic oligonucleotides. Depending on substitution patterns at the

Study of synthesis and cardiovascular activity of some furoxan derivatives as potential NO-donors

A series of hybrid molecules incorporating the furoxan and nicorandil moieties were designed as potential NO donors with cardiovascular and cerebrovascular activities. Thirty-six target molecules were successfully synthesized by conventional methods and characterized by infrared spectroscopy, 1H-NMR spectroscopy and high resolution mass spectra. The compounds were tested for their effects on KCl-induced contraction of rabbit thoracic aorta whose endothelium was denuded. Eight compounds were found to reduce KCl-induced contraction by more than 30% at 10 μM. All except one of these compounds are characterized by the presence of electron withdrawing groups in the phenyl ring attached via an amide or ester linkage to the furoxan moiety. The nature of the terminal carbonyl linkage (ester or amide) and the length or type of the alkyl chain bridging the two carbonyl functions have little effect on the activity. One of the active compounds, N-(4- methoxy-benzoyl)-N'-[3-methylfuroxanyl-4-carbonyl)piperazine (17i) was tested for hypotensive effects on anaesthetized rats at 1.5 mg/kg, and found to demonstrate a gradual and sustained hypotensive effect. The results suggest that the furoxannicorandil derivatives are a useful lead in the design of NO- donor compounds for hypertension.

N-[hydroxy(amino)alkyl]amides of amino(nitro)benzoic acids

2-Aminoethanol and 3-amino-1-propanol react with methyl 3-nitro-and 4-nitrobenzoates in boiling toluene to afford the corresponding ethyl N-(hydroxyalkyl)nitrobenzoates. The reaction of methyl 3-nitro-and 4-nitrobenzoates with bis(2-hydroxyethyl)amine yie