7399-69-1Relevant articles and documents
Benzimidazolium-based receptors: Case of iodide-water cluster induced supramolecular chain and improved fluorometric binding of iodide involving alcoholic group
Ghosh, Kumaresh,Saha, Indrajit
, p. 57 - 65 (2013/06/26)
Benzimidazolium-based receptors 1 and 2 have been designed and synthesized. Anion binding studies reveal their selective fluorescence sensing of iodide in the excited state by exhibiting greater quenching of emission of anthracene. In the ground state, they prefer to bind bromide ion. Incorporation of alcoholic -OH in 2 leads to better performance over the receptor 1. The cyclooctameric structure as constituted by inclusion water and iodide interaction leads to ID-supramolecular chain with the structure 1 in the solid state. 1H NMR, UV-vis and fluorescence spectroscopic methods were adopted to study the anion binding behavior.
2-Benzamidoethyl group - A novel type of phosphate protecting group for oligonucleotide synthesis
Guzaev,Manoharan
, p. 783 - 791 (2007/10/03)
A number of 5′-O-(4,4′-dimethoxytrityl)thymidine N,N-diisopropylamino phosphoramidites protected at P(III) with derivatives of 2-benzamidoethanol were synthesized and incorporated into synthetic oligonucleotides. Depending on substitution patterns at the
Study of synthesis and cardiovascular activity of some furoxan derivatives as potential NO-donors
Mu, Li,Feng, Si-Shen,Go, Mei Lin
, p. 808 - 816 (2007/10/03)
A series of hybrid molecules incorporating the furoxan and nicorandil moieties were designed as potential NO donors with cardiovascular and cerebrovascular activities. Thirty-six target molecules were successfully synthesized by conventional methods and characterized by infrared spectroscopy, 1H-NMR spectroscopy and high resolution mass spectra. The compounds were tested for their effects on KCl-induced contraction of rabbit thoracic aorta whose endothelium was denuded. Eight compounds were found to reduce KCl-induced contraction by more than 30% at 10 μM. All except one of these compounds are characterized by the presence of electron withdrawing groups in the phenyl ring attached via an amide or ester linkage to the furoxan moiety. The nature of the terminal carbonyl linkage (ester or amide) and the length or type of the alkyl chain bridging the two carbonyl functions have little effect on the activity. One of the active compounds, N-(4- methoxy-benzoyl)-N'-[3-methylfuroxanyl-4-carbonyl)piperazine (17i) was tested for hypotensive effects on anaesthetized rats at 1.5 mg/kg, and found to demonstrate a gradual and sustained hypotensive effect. The results suggest that the furoxannicorandil derivatives are a useful lead in the design of NO- donor compounds for hypertension.
