88186-35-0

Usage

Type of compound

Heterocyclic

Structure

Contains a five-membered oxazole ring with a nitrophenyl group attached

Usage

Pharmaceutical and agrochemical industries as a building block for the synthesis of various organic compounds

Potential biological activities

Antimicrobial and anticancer properties

Upstream product

• 7127-19-7 2-phenyl-1,3-oxazoline 
• 340825-85-6 3-nitro-benzoic acid-(2-bromo-ethylamide) 
• 1517-05-1 2-azidoethanol 
• 99-61-6 3-nitro-benzaldehyde 
• 860682-01-5 3-nitro-benzoic acid-(2-chloro-ethylamide) 
• 619-25-0 3-Nitrobenzyl alcohol 
• 141-43-5 ethanolamine 
• 121-90-4 m-nitrobenzoic acid chloride 
• 7399-69-1 N-(2-hydroxyethyl)-3-nitrobenzamide 

Downstream Products

• 81187-71-5 2-(3-aminophenyl)-Δ²-oxazoline 
• 35582-07-1 2-(m-Nitrophenyl)oxazole 
• 1322669-55-5 C₁₈H₁₄ClN₃O 

Relevant academic research and scientific papers

An efficient one-pot synthesis of 2-oxazolines with molecular iodine under ultrasound irradiation

A series of 2-oxazolines were prepared by the condensation of aldehydes with 2-aminoethanol in the presence of molecular iodine and potassium carbonate in t-BuOH at 35-40 °C under ultrasound irradiation. The easy work-up procedure and moderate to good yie

A convenient synthesis of 2-oxazolines and 2-benoxazoles with PPh3-DDQ as the dehydrating reagent

2-Oxazolines and 2-benoxazoles were synthesized in high yields from acylamino alcohols and acylaminophenols, respectively, with triphenylphosphine- 2,3-dichloro-5,6-dicyanobenzoquinone (PPh3-DDQ) as the dehydrating and activating reagent. The synthesis was accomplished under neutral conditions.

Poly(N-bromo-N-ethyl-benzene-1,3-disulfonamide), N,N,N′,N′- tetrabromobenzene-1, 3-disulfonamide as new efficient reagents for conversion of alcohols to THP ethers and aldehydes to oxazoline compounds

This paper is concerned with an easy preparation of THP ethers from primary, secondary and tertiary alcohols and oxazoline compounds from various aldehydes using poly(N-bromo-N-ethyl-benzene-1,3-disulfonamide), N,N,N′,N′-tetrabromobenzene-1,3-disulfonamide [TBBDA] as new and efficient reagents under ambient conditions without over-oxidation.

A facile synthesis of 2-oxazolines using a PPh3-DDQ system

A facile and efficient synthesis of 2-oxazolines from N-(2-hydroxyethyl)amides using a triphenylphosphine-2,3-dichloro-5,6-dicyanobenzoquinone (PPh3-DQQ) system is described. The reaction proceeds under neutral and mild conditions, and excellent yields are obtained.

Direct oxidative conversion of aldehydes and alcohols to 2-imidazolines and 2-oxazolines using molecular iodine

Aldehydes were converted to the corresponding 2-imidazolines and 2-oxazolines in good yields by the reaction with ethylenediamine and aminoethanol, respectively, using molecular iodine and potassium carbonate. Moreover, primary alcohols were directly converted to the corresponding 2-imidazolines and 2-oxazolines via aldehydes in one-pot manner with ethylenediamine and aminoethanol, respectively, using molecular iodine and potassium carbonate.

The Use of 2-Oxazolidinone as a Latent Aziridine Equivalent. I. A Facile Method for the Preparation of 2-Substituted Oxazolines

Ring-opening reaction of 2-oxazolidinone with acid chlorides followed by treatment with aqueous sodium hydroxide yields 2-substituted oxazolines.