88186-35-0

Basic information

• Product Name: 2-(3-nitrophenyl)-4,5-dihydro-1,3-oxazole
• CAS NO: 88186-35-0
• Molecular Formula: C₉H₈N₂O₃
• Molecular Weight: 192.1714
• Mol File: 88186-35-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 342.2°C at 760 mmHg
• Flash Point: 160.8°C
• Density: 1.4g/cm³
• Vapor Pressure: 0.000151mmHg at 25°C
• Refractive Index: 1.634
• CAS DataBase Reference: 2-(3-nitrophenyl)-4,5-dihydro-1,3-oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-nitrophenyl)-4,5-dihydro-1,3-oxazole(88186-35-0)
• EPA Substance Registry System: 2-(3-nitrophenyl)-4,5-dihydro-1,3-oxazole(88186-35-0)

Safety Data

• Hazardous Substances Data: 88186-35-0(Hazardous Substances Data)

Usage

Type of compound

Heterocyclic

Structure

Contains a five-membered oxazole ring with a nitrophenyl group attached

Usage

Pharmaceutical and agrochemical industries as a building block for the synthesis of various organic compounds

Potential biological activities

Antimicrobial and anticancer properties

Upstream product

• 1517-05-1 2-azidoethanol 
• 99-61-6 3-nitro-benzaldehyde 
• 141-43-5 ethanolamine 
• 7399-69-1 N-(2-hydroxyethyl)-3-nitrobenzamide 
• 121-90-4 m-nitrobenzoic acid chloride 
• 619-25-0 3-Nitrobenzyl alcohol 
• 860682-01-5 3-nitro-benzoic acid-(2-chloro-ethylamide) 
• 340825-85-6 3-nitro-benzoic acid-(2-bromo-ethylamide) 
• 7127-19-7 2-phenyl-1,3-oxazoline 

Downstream Products

• 81187-71-5 2-(3-aminophenyl)-Δ²-oxazoline 
• 1322669-55-5 C₁₈H₁₄ClN₃O 
• 35582-07-1 2-(m-Nitrophenyl)oxazole 

Relevant articles and documents

An efficient one-pot synthesis of 2-oxazolines with molecular iodine under ultrasound irradiation

A series of 2-oxazolines were prepared by the condensation of aldehydes with 2-aminoethanol in the presence of molecular iodine and potassium carbonate in t-BuOH at 35-40 °C under ultrasound irradiation. The easy work-up procedure and moderate to good yie

Poly(N-bromo-N-ethyl-benzene-1,3-disulfonamide), N,N,N′,N′- tetrabromobenzene-1, 3-disulfonamide as new efficient reagents for conversion of alcohols to THP ethers and aldehydes to oxazoline compounds

This paper is concerned with an easy preparation of THP ethers from primary, secondary and tertiary alcohols and oxazoline compounds from various aldehydes using poly(N-bromo-N-ethyl-benzene-1,3-disulfonamide), N,N,N′,N′-tetrabromobenzene-1,3-disulfonamide [TBBDA] as new and efficient reagents under ambient conditions without over-oxidation.

Direct oxidative conversion of aldehydes and alcohols to 2-imidazolines and 2-oxazolines using molecular iodine

Aldehydes were converted to the corresponding 2-imidazolines and 2-oxazolines in good yields by the reaction with ethylenediamine and aminoethanol, respectively, using molecular iodine and potassium carbonate. Moreover, primary alcohols were directly converted to the corresponding 2-imidazolines and 2-oxazolines via aldehydes in one-pot manner with ethylenediamine and aminoethanol, respectively, using molecular iodine and potassium carbonate.