73992-23-1Relevant academic research and scientific papers
Olefinic Nitrone and Nitrile Oxide Cycloadditions. A Short Stereospecific Synthesis of Biotin from Cycloheptene
Confalone, Pat N.,Pizzolato, Giacomo,Confalone, Dianne Lollar,Uskokovic Milan R.
, p. 1954 - 1960 (1980)
A novel synthesis of biotine (6) from cycloheptene (4) via the key amino alcohol 5 is described.The synthetic scheme is based upon an intramolecular nitrone-olefin cycloaddition of the reactive intermediate 13, generated in situ from the aldehyde
