73994-51-1

Upstream product

• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 1068-90-2 2-acetylaminomalonic acid diethyl ester 

Downstream Products

• 73994-54-4 2-(2-Chloro-acetylamino)-4-(4-hydroxy-phenyl)-4-oxo-butyric acid 
• 74034-99-4 β-(4-hydroxybenzoyl)alanine 
• 168154-99-2 D,L-4-Oxo-homotyrosinmethylaether-hydrochlorid 
• 61172-78-9 D,L-4-Oxo-homotyrosin 

Relevant academic research and scientific papers

24. Stoffwechselprodukte von Mikroorganismen. Ueber das 4-Oxo-homotyrosin, ein Abbauprodukt des Echinocandins B

D,L-4-Oxo-homotyrosine was synthesized by the acetylaminomalonic ester pathway.The optical resolution was carried out by means of the enzyme acylase I.The L-configuration of the enzymatically produced amino acid was confirmed by degradation to L-aspartic acid. 4-Oxo-homotyrosine obtained by degradation of the polypeptide antibiotic echinocandine B has D-configuration, but his optical purity is low.A hypothetical explanation for its formation from the (2S,3S,4S)-3,4-dihydroxyhomotyrosine residue of echinocandine B is proposed.

2-AMINO-4-PHENYL-4-OXO-BUTYRIC ACID DERIVATIVES

Use in the prevention and/or in the treatment of neurodegenerative diseases of 2-amino-4-phenyl-4-oxo-butyric acid derivatives which act as kynureninase enzyme inhibitors and/or kynurenine-3-hydroxylase enzyme inhibitors. Several of these derivatives are new and, as such, constitute a further object of this invention, together with the process for their preparation and the pharmaceutical compositions containing them.