24. Stoffwechselprodukte von Mikroorganismen. Ueber das 4-Oxo-homotyrosin, ein Abbauprodukt des Echinocandins B

Article abstract of DOI:10.1002/hlca.19800630125

D,L-4-Oxo-homotyrosine was synthesized by the acetylaminomalonic ester pathway.The optical resolution was carried out by means of the enzyme acylase I.The L-configuration of the enzymatically produced amino acid was confirmed by degradation to L-aspartic acid. 4-Oxo-homotyrosine obtained by degradation of the polypeptide antibiotic echinocandine B has D-configuration, but his optical purity is low.A hypothetical explanation for its formation from the (2S,3S,4S)-3,4-dihydroxyhomotyrosine residue of echinocandine B is proposed.