73994-85-1Relevant academic research and scientific papers
Protected Amino Acid Active Esters Incorporating the 4-Picolyl Basic Solubilizing Group
Stewart, Frederick H. C.
, p. 2013 - 2017 (2007/10/02)
The 4-picolyl ester of 4-hydroxy-3-nitrophenylacetic acid has been prepared from an active polyester intermediate, and used as the precursor of a series of protected amino acid active esters.These compounds were satifactory coupling components in peptide syntheses.Purification of the protected peptides by acid washing was facilitated by the presence of the basic 4-picolyl moiety.
Some Ester Derivatives of 2-Methylalanine as Intermediates in Peptide Synthesis
Stewart, Frederick H.C.
, p. 121 - 129 (2007/10/02)
The o-nitrophenylthio derivative of-methylalanine served as the precursor of several new ester hydrochlorides, which have been investigated as intermediates for the synthesis of peptides containing this amino acid.Particular consideration is given to the effect of the steric hindrance associated with 2-methylalanine.Synthesis of 2-methylalanyl analogue of the opiate agonist leucine-enkephalin is described.
