73997-09-8Relevant academic research and scientific papers
Synthesis of new azolo[5,1-d][1,2,3,5]tetrazin-4-ones–analogs of antitumor agent temozolomide
Sadchikova
, p. 1867 - 1872 (2017/03/22)
Reactivity of 5-diazoimidazoles and 5-diazopyrazoles in the reactions with alkyland aryl isocyanates was studied. A number of new imidazo-and pyrazolo[5,1-d][1,2,3,5]tetrazin-4 ones were synthesized, which are analogs of temozolomide. It was shown that diazoazoles do not react with isothiocyanates under similar conditions.
Synthesis of pyrazolo[5,1-d][1,2,3,5]tetrazine-4(3H)-ones
Gao, Yaojun,Lam, Yulin
experimental part, p. 69 - 74 (2010/10/04)
A solid-phase synthesis of 5-aminopyrazole has been developed and applied to the preparation of pyrazolo[5,1-d]-[1,2,3,5]tetrazine-4(3H)-ones. In this strategy, a one-pot reaction from 5-aminopyrazoles to the pyrazolo[5,1-d]-[1,2, 3,5]tetrazine-4(3H)-ones which provided the compounds in good yields was demonstrated. Using this synthetic strategy, we prepared a representative set of 16 pyrazolo[5,1-d][l,2,3,5]tetrazine-4(3H)-ones.
