740-86-3

Basic information

• Product Name: 4-methoxy-benzaldehyde 4-(4-methoxy-phenyl)-thiosemicarbazone
• Synonyms: 4-methoxy-benzaldehyde 4-(4-methoxy-phenyl)-thiosemicarbazone
• CAS NO: 740-86-3
• Molecular Weight: 315.396
• Mol File: 740-86-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-methoxy-benzaldehyde 4-(4-methoxy-phenyl)-thiosemicarbazone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methoxy-benzaldehyde 4-(4-methoxy-phenyl)-thiosemicarbazone(740-86-3)
• EPA Substance Registry System: 4-methoxy-benzaldehyde 4-(4-methoxy-phenyl)-thiosemicarbazone(740-86-3)

Safety Data

• Hazardous Substances Data: 740-86-3(Hazardous Substances Data)

Upstream product

• 104-94-9 4-methoxy-aniline 
• 40207-03-2 p-Anisidinothioformyl-hydrazin 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 803-68-9 4-methoxy-benzaldehyde [3-(4-methoxy-phenyl)-5-methyl-4-oxo-thiazolidin-2-ylidene]-hydrazone 
• 802-05-1 4-methoxy-benzaldehyde [3-(4-methoxy-phenyl)-4-oxo-thiazolidin-2-ylidene]-hydrazone 
• 809-20-1 4-methoxy-benzaldehyde [3-(4-methoxy-phenyl)-4-oxo-5-phenyl-thiazolidin-2-ylidene]-hydrazone 

Relevant articles and documents

Thio- and selenosemicarbazones as antiprotozoal agents against Trypanosoma cruzi and Trichomonas vaginalis

Herein, we report the preparation of a panel of Schiff bases analogues as antiprotozoal agents by modification of the stereoelectronic effects of the substituents on N-1 and N-4 and the nature of the chalcogen atom (S, Se). These compounds were evaluated towards Trypanosoma cruzi and Trichomonas vaginalis. Thiosemicarbazide 31 showed the best trypanocidal profile (epimastigotes), similar to benznidazole (BZ): IC50 (31)=28.72 μM (CL-B5 strain) and 33.65 μM (Y strain), IC50 (BZ)=25.31 μM (CL-B5) and 22.73 μM (Y); it lacked toxicity over mammalian cells (CC50 > 256 μM). Thiosemicarbazones 49, 51 and 63 showed remarkable trichomonacidal effects (IC50?=16.39, 14.84 and 14.89 μM) and no unspecific cytotoxicity towards Vero cells (CC50 ≥ 275 μM). Selenoisosters 74 and 75 presented a slightly enhanced activity (IC50=11.10 and 11.02 μM, respectively). Hydrogenosome membrane potential and structural changes were analysed to get more insight into the trichomonacidal mechanism.

On the synthesis of fused thiazolo[5,4-d]isoxazoles and a novel rearrangement involving conversion of 5(4H)-isoxazolones to 4(5H)-isoxazolones

The interaction of 4-bromo-3-substituted-(4H)-isoxazol-5-ones (1) with alkyl/aryl thiocarbamides (2), 4-alkyl/aryl thiosemicarbazides (7) and 2, 4-disubstituted thiosemicarbazides (12) afford 5-alkyl/ arylamino-3-substituted-thiazolo [5, 4-d]isoxazoles (3) and 6-amino/anilino-5-alkyl/arylimino-3-substituted-thiazolo[5, 4-d]isoxazoles respectively. An alternate unambiguous one step synthesis is described. The compounds have been characterised by chemical reactions and spectral data.