7400-44-4Relevant academic research and scientific papers
Nucleoside Conjugates. 13. Synthesis and Antitumor Activity of 1-β-D-Arabinofuranosylcytosine Conjugates of Thioether Lipids with Improved Water Solubility
Hong, Chung Il,Nechaev, Alexander,Kirisits, Alan J.,Vig, Rakesh,West, Charles R.
, p. 1785 - 1790 (2007/10/02)
A series of ara-CDP-rac-1-S-alkyl-2-O-acyl-1-thioglycerols (3-12), analogues of highly active Cytoros (1), was prepared, and solubility, lipophilicity, and structure-activity relationships of these conjugates were investigated.The conjugates with sn-1 alk
Nucleoside conjugates. 11. Synthesis and antitumor activity of 1-β-D-arabinofuranosylcytosine and cytidine conjugates of thioether lipids
Il Hong,Kirisits,Nechaev,Buchheit,West
, p. 1380 - 1386 (2007/10/02)
Five 1-β-D-arabinofuranosylcytosine conjugates and two cytidine conjugates of thioether lipids (1-S-alkylthioglycerols) linked by a pyrophosphate diester bond have been prepared and their antitumor activity against an ara-C2 sensitive (L1210/0)
SYNTHESE DE LA d,l-(ACETOXY-2 OCTADECYLTHIO-1) PROPYL-3 PHOSPHORYLCHOLINE OU THIA-PAF
Garrigues, Bernard,Bertrand, Guy,Frehel, Daniel,Maffrand, Jean-Pierre
, p. 171 - 176 (2007/10/02)
d,l-thia-PAF 2 was synthesised using a selective method of protection (ClSiMe2t-Bu) and deprotection (BF3-Et2O) of the primary alcohol function.This method could be used with advantage in the syn
SYNTHESIS OF ALKYLTHIOGLYCEROLS AND THEIR DIACYL DERIVATIVES
Malina, E.V.,Serebrennikova, G.A.,Evstigneeva, R.P.
, p. 840 - 841 (2007/10/02)
1-Hexadecylthio-rac-glycerol and 1-octadecylthio-rac-glycerol were synthesized by the reaction of 1-bromo-1-deoxy-2,3-isopropylidene-rac-glycerol and higher alkanethiols with subsequent removal of the isopropylidene protection. 1-Hexadecylthio-2,3-dipalmitoyl-rac-glycerol and 1-hexadecylthio-2,3-distearoyl-rac-glycerol were also obtained directly from 1-hexadecylthio-2,3-isopropylidene-rac-glycerol and palmitoyl and stearoyl chlorides.
