74002-71-4Relevant academic research and scientific papers
BICYCLIC HETEROARENES AND METHODS OF THEIR USE
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Page/Page column 95, (2021/12/30)
Disclosed are compounds useful in the treatment of neurological disorders. The compounds described herein, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological diseases.
Silver-free two-component approach in gold catalysis: Activation of [LAuCl] complexes with derivatives of copper, zinc, indium, bismuth, and other lewis acids
Fang, Weizhen,Presset, Marc,Guerinot, Amandine,Bour, Christophe,Bezzenine-Lafollee, Sophie,Gandon, Vincent
supporting information, p. 5439 - 5446 (2014/05/20)
Complexes of type [LAuCl] (L=phosphine, phosphite, NHC and others) are widely employed in homogeneous catalysis, however, they are usually inactive as such and must be used jointly with a halide scavenger. To date, this role has mostly been entrusted to silver salts (AgSbF6, AgPF6, AgBF4, AgOTf, etc.). However, silver salts can be the source of deactivation processes or side reactions, so it is sometimes advisable to use silver-free cationic gold complexes, which can be difficult to synthesize and to handle compared with the more robust chloride. We show in this study that various Lewis acids of the transition and main group metal families are expedient substitutes to silver salts. We have tested CuI, Cu II, ZnII, InIII, SiIV, Bi III, and other salts in a variety of typical AuI-catalyzed transformations, and the results have revealed that [LAuCl] can form active species in their presence. Not just silver: Active gold species have been generated from the corresponding inactive chlorides by using Lewis acids that are not typical in gold chemistry (see figure). Instead of silver salts, complexes of Cu, Zn, In, Si, Bi, and others have been used. This study shows that silver salts, which can cause deactivation processes and side reactions, can be replaced by various activators. Thus, the use of a sensitive cationic gold complex can be avoided.
Triflic acid mediated dealkylative lactonisation via NMR-observable alkyloxonium intermediates
Munoz, M. Paz,Lloyd-Jones, Guy C.
experimental part, p. 516 - 524 (2009/07/19)
Trifluoromethanesulfonic acid (TfOH) efficiently induces the dealkylative cyclisation of pent-4-enoates to generate γ-lac-tones with high selectivity. For primary alkyl esters bearing an additional alkene, only monolactonisation occurs, even in the presen
Stereoselective radical Aryl migration reactions from sulfur to carbon
Bossart, Martin,Faessler, Roger,Schoenberger, Jan,Studer, Armido
, p. 2742 - 2757 (2007/10/03)
Stereoselective aryl migration reactions from sulfur in sulfonates and sulfonamides to C-centered radicals are reported. The 1,5-aryl migration from sulfur to differently substituted C-centered radicals could be performed with high yields and selectivities. Functionalized aryl groups could also be transferred by this new method. A model to explain the stereochemical outcome of the reaction is presented and some mechanistic aspects of this reaction are discussed. Aryl migration reactions from sulfur in sulfinates to carbon radicals were less efficient, and the corresponding migrations in aryl sulfoxides were not observed at all. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.
Studies on New Synthetic Pathways to Δα,β-Butenolides from α-Methylbutanolides. II. Electrolytic Oxidation of Simple α-Carboxy-α-methylbutanolides
Kawamata, Takeshi,Inayama, Seiichi,Sata, Kazuko
, p. 277 - 281 (2007/10/02)
A new approach to the synthesis of Δα,β-butenolides from γ-butanolides by means of the electrolytic oxidation of α-carboxy-α,γ-dimethyl-γ-butyrolactone (3b) and its α-carboxy-α-methyl analog (3d) resulted in predominant formation of the endocyc
