74003-63-7

Usage

Uses

Used in Agricultural Industry:
3-Methylquinoxaline-2-carboxylic acid is used as a marker compound for the detection of olaquindox use in livestock applications. This helps in monitoring and ensuring the safety and quality of meat products derived from treated animals.
Used in Research and Development:
MQCA is utilized in research studies to understand the effects of olaquindox metabolites on cell cycle regulation and toxicity. This aids in the development of safer and more effective alternatives to olaquindox in animal husbandry and agriculture.

InChI:InChI=1/C10H8N2O2/c1-6-9(10(13)14)12-8-5-3-2-4-7(8)11-6/h2-5H,1H3,(H,13,14)

Upstream product

• 480-96-6 benzofurazan oxide 
• 24309-97-5 N-(2-hydroxyethyl)-3-oxobutanamide 
• 88-74-4 2-nitro-aniline 
• 61522-54-1 methyl 3-methylquinoxaline-2-carboxylate 
• 2379-55-7 2,3-dimethylquinoxaline 
• 3885-38-9 2-methyl-3-ethoxycarbonylquinoxaline 
• 7446-08-4 selenium(IV) oxide 
• 108-38-3 m-xylene 
• 25519-55-5 3-methylquinoxaline-2-carbaldehyde 
• 13297-18-2 2-ethoxycarbonyl-3-methylquinoxaline 1,4-dioxide 

Relevant academic research and scientific papers

Preparation method of high-purity 3-methylquinoxaline-2-carboxylic acid

The invention discloses a preparation method of high-purity 3-methylquinoxaline-2-carboxylic acid. The preparation method comprises the following steps: enabling a compound shown as a formula III to react with acetate to obtain a compound shown as a formula II; enabling the compound shown as the formula II to react with o-phenylenediamine under an acidic condition to prepare a compound shows as aformula I; then, preparing the 3-methylquinoxaline-2-carboxylic acid from the compound shown as the formula I. The preparation method has the advantages of short process route, easiness and convenience in operation, mild conditions, readily-available raw materials, and higher yield and purity of the obtained product. As proved by results of qualitative and quantitative analysis performed on the product by the analysis measures of magnetic resonance imaging, high performance liquid chromatography, gas chromatography and the like, the moisture and solvent residue content in the product are extremely low, and a sample has high uniformity and storage stability, and meets the requirement as a standard product. The formulas I, II and III are shown in the description.

Synthesis of the possible metabolites of quinocetone in animals

The possible metabolites of quinocetone in animals had been prepared with different selective reagent by three synthetic routes. It was their principal reaction that Na2S2O4 reduced quinoxaline-1,4-dioxide derivatives to quinoxaline derivatives, H 2O2 s oxidized 2-carboxyl-quinoxaline derivatives to 2-carboxyl-quinoxaline-1 -oxide ones and P(OCH3) 3 reduced 2-carboxyl- quinoxaline-1,4-dioxide derivatives to 3-carboxyl-quinoxaline-1-oxide ones. The title compounds ware confirmed with NMR,UV, FAB-MS, et al.

Oxidation of 2,3-Dimethyl-quinoxaline and 2,4-Dimethyl-quinazoline with Selenium Dioxide

The primary oxidation products of 2,3-dimethylquinoxaline with selenium dioxide are 3-methylquinoxaline-2-carbaldehyde, 1,3-dihydro-1,3-dihydroxyfuroquinoxaline and quinoxaline-2-carboxylic acid. 3-Methylquinoxaline-2-carboxylic acid can be obtained in a second oxidation step only. 2,4-Dimethylquinazoline is dehydrogenated by selenium dioxide to the heterocyclic stilbene derivative 8.Confirmation of structure of 8 is given by NMR spectroscopy. - Keywords: Oxidation of methyl groups; SeO2; Quinoxaline; Quinazoline

An Improved and Efficient Synthesis of Quinoxalinecarboxamide 1,4-Dioxides from Benzofuroxan and Acetoacetamides in the Presence of Calcium Salts

An improved and efficient method for the preparation of the title compounds 3 is described.Thus, quinoxalinecarboxamide 1,4-dioxides 3 are synthesized in high yields by reaction of benzofuroxan 1 with acetoacetamides 2 in the presence of catalytic amounts of calcium salts and ethanolamine.The reaction is assumed to involve a chelate mechanism with 4 as intermediate.Side reactions are studied by means of HPLC and TLC.

Substituted alkyl esters of quinoxaline-di-N-oxide-2-carboxylic acid

Novel alkyl esters of quinoxaline-di-N-oxide-2-carboxylic acid substituted on the alkyl portion of the ester by hydroxy, acyloxy, N-alkyl carbamyloxy, dialkylaminoacyloxy, carboxyacyloxy, alkoxycarbonyloxy, haloacyloxy, amino and mono- and disubstituted amino, useful as antibacterial agents and in promoting growth and improving feed efficiency of animals in general.