740055-30-5

Usage

Uses

Used in Organic Synthesis:
D-Homophenylalanine tert-Butyl Ester is used as a building block for the synthesis of peptides and small molecules, contributing to the development of complex organic compounds and pharmaceutical agents.
Used in Pharmaceutical Research:
In pharmaceutical research, D-Homophenylalanine tert-Butyl Ester is utilized as a precursor in the design and synthesis of novel drugs, targeting various biological pathways and mechanisms.
Used in Enzyme and Receptor Inhibition:
D-Homophenylalanine tert-Butyl Ester is studied for its potential as an inhibitor of specific enzymes and receptors, which can be instrumental in treating diseases by modulating biological processes.
Used in Chemical Reaction Protection:
The tert-butyl ester group in D-Homophenylalanine tert-Butyl Ester provides protection to the amino acid during chemical reactions, ensuring that the compound's reactivity and functionality are preserved for subsequent steps in synthesis.
Used in Biochemical and Biomedical Research:
In biochemical and biomedical research, D-Homophenylalanine tert-Butyl Ester is employed to explore its interactions with biological systems, offering insights into its potential therapeutic effects and mechanisms of action.

Downstream Products

• 1402160-02-4 C₂₉H₃₁NO₄ 
• 105382-09-0 (R)-2-amino-4-phenylbutanoic acid hydrochloride 
• 1402160-03-5 C₂₁H₂₅NO₃ 
• 1622863-21-1 (R)-tert-butyl 2-(4-amino-3-(4-hydroxyphenethyl)benzamido)-4-phenylbutanoate 
• 1205122-35-5 (R)-N-hydroxy-2-[(3-methyl-butyl)-(naphthalene-2-sulfonyl)-amino]-4-phenyl-butyramide 
• 1356406-84-2 C₂₅H₂₉NO₄S 

Relevant academic research and scientific papers

Asymmetric Synthesis of α-Amino Acids by Organocatalytic Biomimetic Transamination

A biomimetic enantioselective transamination of α-keto ester derivatives can be realized under mild conditions by using chiral quaternary ammonium arenecarboxylates in the absence of base additives. The corresponding α-amino acids can be used as versatile intermediates for further synthetic transformations that furnish chiral pyrrolidine and octahydroindolizine derivatives.

An efficient asymmetric biomimetic transamination of α-keto esters to chiral α-amino esters

An efficient asymmetric biomimetic transamination of α-keto esters with quinine derivatives as chiral bases was described. A wide variety of α-amino esters containing various functional groups can be synthesized in high yield and enantioselectivity.

The effect of benzyl amine on the efficiency of the base-catalyzed transamination of α-keto esters

This paper describes the effect of benzyl amine on the base-catalyzed transamination of α-keto esters. Among various benzyl amines examined, o-HOC6H4CH2NH2 was found to be highly effective for the reaction, affording a wide variety of α-amino esters in good yields. The o-OH group of the benzyl amine facilitates the transamination process likely via H-bond. Moderate enantiomeric excess was obtained for α-amino ester when a quinine derived catalyst was used.