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7401-22-1

Podophyllotoxin chloride is a naturally occurring chemical compound derived from the Podophyllum plant species, particularly Podophyllum peltatum and Podophyllum emodi. It is a white crystalline substance with a molecular formula of C22H22O8Cl2 and is known for its potent cytotoxic properties. Podophyllotoxin chloride has been widely studied for its potential use in cancer treatment, as it inhibits cell division by disrupting the microtubules in the cell's mitotic spindle. Podophyllotoxin chloride has been used as a precursor in the synthesis of several chemotherapeutic agents, such as etoposide, teniposide, and etopophos, which are used to treat various types of cancer. Due to its toxicity, podophyllotoxin chloride is not used directly in medicine but serves as an important intermediate in the production of these life-saving drugs.

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  • 7401-22-1 Structure

  • Basic information

    1. Product Name: Podophyllotoxin chloride
    2. Synonyms:
    3. CAS NO:7401-22-1
    4. Molecular Formula: C22H21ClO7
    5. Molecular Weight: 432.858
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 7401-22-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 583.1°Cat760mmHg
    3. Flash Point: 212.9°C
    4. Appearance: N/A
    5. Density: 1.43g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: Podophyllotoxin chloride(CAS DataBase Reference)
    10. NIST Chemistry Reference: Podophyllotoxin chloride(7401-22-1)
    11. EPA Substance Registry System: Podophyllotoxin chloride(7401-22-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 7401-22-1(Hazardous Substances Data)

7401-22-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 7401-22-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,4,0 and 1 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 7401-22:
(6*7)+(5*4)+(4*0)+(3*1)+(2*2)+(1*2)=71
71 % 10 = 1
So 7401-22-1 is a valid CAS Registry Number.

7401-22-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-chloro-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one

1.2 Other means of identification

Product number -
Other names 9-chloro-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5ah)-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:7401-22-1 SDS

7401-22-1Upstream product

7401-22-1Relevant articles and documents

Azepines by Photochemical Ring Enlargement of 9-Azidopodophyllotoxin- and 9-Azido-9'-demethylepipodophyllotoxin Derivatives

Laatsch, Hartmut,Ernst, Bernd Peter,Hoffmann, Dieter

, p. 1773 - 1778 (2007/10/03)

The azepines 5a-5c were obtained by photochemical nitrene rearrangement of the azides 1e/1f and 4b/4c in cyclohexene, but not in other solvents.They are ring expansion products of podophyllotoxin (1a) and resemble steganacin (9), but show only low biological activity.The triazenes 7a/8a and the aziridine 8b are also less active than 1a. - Keywords: Podophyllotoxin / Podophyllotoxin azides / Nitrene rearrangement

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