155252-34-9

Upstream product

• 518-28-5 podofilox 
• 4375-07-9 epipodophyllotoxin 
• 908355-89-5 Methanesulfonic acid (5R,5aR,8aR,9R)-8-oxo-9-(3,4,5-trimethoxy-phenyl)-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl ester 
• 7401-22-1 9-Chloro-9-desoxypodophyllotoxin 

Downstream Products

• 1092371-34-0 9-(4-phenylaminomethyl-[1,2,3]triazol-1-yl)-5-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one 
• 1092371-36-2 9-{4-[(2-chloro-phenylamino)-methyl]-[1,2,3]triazol-1-yl}-5-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one 
• 1092371-37-3 9-[4-(p-tolylamino-methyl)-[1,2,3]triazol-1-yl]-5-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one 
• 1092371-30-6 9-{4-[(3-chloro-phenylamino)-methyl]-[1,2,3]triazol-1-yl}-5-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one 
• 1092371-31-7 9-{4-[(3-chloro-phenylamino)-methyl]-[1,2,3]triazol-1-yl}-5-(4-hydroxy-3,5-dimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one 
• 1092371-28-2 9-[4-(o-tolylamino-methyl)-[1,2,3]triazol-1-yl]-5-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one 
• 1334229-12-7 4β-(4-pyridyl-1,2,3-triazole)-podophyllotoxin 
• 1334229-13-8 4β-(5-pyridyl-1,2,3-triazole)-podophyllotoxin 
• 1334229-14-9 4β-(4-(N,N-dimethylamino)methylene-1,2,3-triazole)-podophyllotoxin 
• 1334229-11-6 4β-(4-(2-carboxyl)-ethyl-1,2,3-triazole)-podophyllotoxin 
• 1203583-25-8 4β-[4-(2-chlorophenylaminocarbonyl)-1,2,3-triazole]-podophyllotoxin 
• 1203583-10-1 C₃₂H₃₀N₄O₈ 
• 1203583-14-5 4β-[5-(4-methylphenylamino-carbonyl)-1,2,3-triazole]-podophyllotoxin 
• 1203583-02-1 4β-(4-(N,N-diethylamino)carbonyl-1,2,3-triazole)-podophyllotoxin 

Relevant academic research and scientific papers

Synthesis of novel 4β-(1,2,3-triazol-1-yl) podophyllotoxins as potential antitumor drugs

The synthesis, characterization and in vitro antitumor activity of two novel podophyllotoxins, 4β-(5-methyl-1,2,3-triazol-1-yl)podophyllotoxin (5) and 4β-(5-phenyl-1,2,3-triazol-1-yl)podophyllotoxin (6), are described.

Synthesis and insecticidal activity of novel 4beta-halogenated benzoylamino podophyllotoxins against Pieris rapae Linnaeus.

Twelve new 4beta-halogenated benzoylamino compounds (7.1-7.12) of podophyllotoxin have been synthesized, and their structures were confirmed by IR, 1H-NMR, MS spectra as well as CHN elemental analysis. These compounds showed delayed insecticidal activity

One-pot synthesis of podophyllotoxin-thiourea congeners by employing NH2SO3H/NaI: Anticancer activity, DNA topoisomerase-II inhibition, and apoptosis inducing agents

A facile one-pot method for the synthesis of novel podophyllotoxin-thiourea congeners has been developed by using NH2SO3H/NaI system. Interestingly, 4β-azido podophyllotoxin reduction with concomitant aryl isothiocyanates coupling un

Synthesis, antitumor activity, and molecular docking of (?)-epigallocatechin-3-gallate-4β-triazolopodophyllotoxin conjugates

Two new (?)-epigallocatechin-3-gallate-4β-triazolopodophyllotoxin conjugates (7 and 8) were synthesized and evaluated for biological activity. Compound 8 showed highly potent anticancer activity against A-549 cell line with IC50 of 2.16 ± 1.02

Synthesis and Anticancer Activity of Podophyllotoxin Derivatives

Two series of podophyllotoxin derivatives were synthesized by addition of a 4β-sulfanilamide to or substitution of a 4β-amide into podophyllotoxin. Their cytotoxicities were evaluated against four human cancer cell lines (A549, HeLa, MCF-7, and PC-3). Inv

Synthesis and antitumor activity of camptothecin- 4β-triazolopodophyllotoxin conjugates

Two new compounds (9 and 10) having a camptothecin (CPT) analog conjugated to the 4β-azido-4-deoxypodophyllotixin analog by untilizing the copper-catalyzed azide-alkyne cycloadditon (CuAAC) reaction, and were evaluated for their cytotoxicity against a panel of five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW480) using the MTT (3-(4,5-dimethyl-thiahiazo-2-yl)-2,5-diphenyltetrazolium bromide) assay. Two novel conjugates shown weak cytotoxicity, compound 10 showed highly potent against HL-60 cell line tested, with IC50 value 17.69 ± 0.19 μM. This compound suggested its potential as anticancer agents for further development. (Figure presented.).

Synthesis and Cytotoxicity of Heterocyclic Amine Derivatives of Podophyllotoxin

A series of amine podophyllotoxin derivatives was designed and synthesized by aldehydes reacting with 4β-amino-desoxypodophyllotoxin or 4′-demethyldesoxypodophyllotoxin. The MTT assay was used to test the cytotoxic activity of 11 target compounds on HeLa

Podophyllotoxin compound containing 1,2,4-triazone structure, and application thereof

The invention discloses a podophyllotoxin compound containing a 1,2,4-triazone structure, and an application thereof. The compound has a structure represented by general formula (I). Podophyllotoxin derivatives containing 1,2,4-triazone, represented by th

Synthesis and Biological evaluation of novel 4β-[(5-substituted)-1,2,3,4-tetrazolyl] podophyllotoxins as anticancer compounds

A series of novel 4β-[(5-substituted)-1,2,3,4-tetrazolyl] podophyllotoxin derivatives were synthesized by employing azide-nitrile click chemistry approach. All the derivatives were evaluated for their cytotoxicity against a panel of four human cancer cell lines and their IC50 values were found to be in the range of 2.4-29.06 μM. The cytotoxicity exhibited by the majority of test compounds were found to comparable and often more effective than doxorubicin and all compounds exhibited higher cytotoxicity on A-549 cell lines. Cell cycle analysis showed that the novel 4β-[(5-substituted)-1,2,3,4-tetrazolyl] podophyllotoxins resulted in cell cycle arrest at G2/M phase and were also found to be the potent inhibitors of tubulin polymerization in vitro.

Differential Targeting of Human Topoisomerase II Isoforms with Small Molecules

(Chemical Equation Presented). The TOP2 poison etoposide has been implicated in the generation of secondary malignancies during cancer treatment. Structural similarities between TOP2 isoforms challenge the rational design of isoform-specific poisons to further delineate these processes. Herein, we describe the synthesis and biological evaluation of a focused library of etoposide analogues, with the identification of two novel small molecules exhibiting TOP2B-dependent toxicity. Our findings pave the way toward studying isoform-specific cellular processes by means of small molecule intervention.