7402-60-0Relevant academic research and scientific papers
Characterization of a cross-reactive electronic nose with vapoluminescent array elements
Drew, Steven M.,Janzen, Daron E.,Mann, Kent R.
, p. 2547 - 2555 (2002)
A three-channel cross-reactive sensor array based on vapoluminescent platinum(II) double salt materials has been characterized. Two arrays were studied, one consisting of [Pt(CN-cyclododecyl)4][Pt(CN)4] (1), [(phen)Pt(CN-cyclohexyl)2][Pt(CN)4] (2), and [Pt(CN-n-tetradecyl)4][Pt(CN)4] (3) materials, where phen = 1,10-phenanthroline, and a second array that has compound 3 replaced by the mixed double salt material [(phen)Pt(CN-cyclododecyl)Cl)]2[(phen)Pt (CN-cyclododecyl)2]2[Pt(CN)4]3 (4). Compounds 2, 3 and 4 are characterized here for the first time. Inclusion of solvent vapors into these materials often leads to dramatic shifts in their solid-state absorption and luminescence spectra. In these studies the arrays were exposed to a set of 10 test solvent vapors to determine the ability of each cross-reactive array to give reproducible vapoluminescent spectra characteristic of each solvent vapor. It was discovered that temperature programming between solvent vapor exposures greatly improved the reproducibility of the luminescence spectra obtained. A statistical analysis of three-dimensional resolution factors between pairs of solvent clusters in principal component space supported this assertion. The success of the temperature programming protocol was limited by the thermal stability and the sensitivity to low background water vapor levels of some platinum(II) double salt materials. The ability of the cross-reactive sensor array to differentiate between two different solvent vapors over a large concentration range was also investigated. Acetone and methanol were found to occupy two distinct regions of the three-dimensional principal component space. Detection limits for acetone and methanol were estimated from the principal component analysis as 75 and 6 g/m3, respectively.
PHYTOSPHINGOSINE DERIVATIVES AS ADJUVANTS IN IMMUNE STIMULATION
-
Page/Page column 44-45, (2022/01/04)
The invention relates to phytosphingosine derivatives, suitable as adjuvants in immune stimulation. The invention further relates to pharmaceutical compositions comprising such compounds and the medical use of said compounds and/or compositions in therapeutic or prophylactic methods of immune stimulation in a subject, and for use in the treatment of a disease, for which stimulation of an immune response in a subject produces a therapeutic benefit. The invention further relates to the phytosphingosine derivative as described herein for use as an adjuvant in a method of vaccinating a subject. The invention further relates to the phytosphingosine derivative as described herein for use in stimulating antibody production, stimulating an immune response against infection, stimulating an immune response against a cancer, or preventing and/or treating septic shock. The invention further relates to a method for the manufacture of said derivatives comprising an Ugi-4-component reaction (Ugi-4CR).
Glycerol as a Building Block for Prochiral Aminoketone, N-Formamide, and N-Methyl Amine Synthesis
Dai, Xingchao,Rabeah, Jabor,Yuan, Hangkong,Brückner, Angelika,Cui, Xinjiang,Shi, Feng
, p. 3133 - 3138 (2016/11/29)
Prochiral aminoketones are key intermediates for the synthesis of optically active amino alcohols, and glycerol is one of the main biomass-based alcohols available in industry. In this work, glycerol was catalytically activated and purposefully converted with amines to generate highly valuable prochiral aminoketones, as well as N-formamides and N-methyl amines, over CuNiAlOx catalyst. The catalyst structure can be anticipated as nano-Ni species on or in CuAlOx via the formation of nano- Cu?Ni alloy particles. This concept may present a novel and valuable methodology for glycerol utilization.
