7404-82-2

Upstream product

• 75-52-5 nitromethane 
• 768-03-6 Phenyl vinyl ketone 
• 936-59-4 3-chloropropiophenone 
• 3506-36-3 3-dimethylaminopropiophenone 
• 58518-86-8 4-nitro-1-phenylbutan-1-one 
• 5724-15-2 N-(2-benzoylethyl)-N,N,N-trimethylammonium iodide 
• 124-41-4 sodium methylate 

Downstream Products

• 181420-63-3 (1S,7S)-(-)-1,7-diphenyl-7-nitroheptan-1,7-diol 
• 181420-58-6 (1R,7R)-(+)-1,7-diphenyl-7-nitroheptan-1,7-diol 
• 102173-17-1 1,5-Dibenzoyl-3-brom-3-nitro-pentan 
• 114695-21-5 1-Phenyl-2-benzoyl-4-(2'-benzoylethyl)-4-nitro-cyclohexanol-⁽¹⁾ 

Relevant academic research and scientific papers

Two-directional synthesis as a tool for diversityoriented synthesis: Synthesis of alkaloid scaffolds

Two-directional synthesis represents an ideal strategy for the rapid elaboration of simple starting materials and their subsequent transformation into complex molecular architectures. As such, it is becoming recognised as an enabling technology for divers

Synthesis of enantiopure 2,7-diaryl-1,6-dioxaspiro[4.4]nonanes via enantioselective reduction of prochiral γ-nitroketones by diisopinocampheylchloroborane (DIP-Cl(TM))

The enantioselective reduction of γ-nitroketones 1-4 and γ-nitrodiketones 5-6 by the chiral reducing agent (+)- or (-)-diisopinocampheylchloroborane (DIP-Cl(TM)) afforded respectively nitroalcohols 7-9 with e.e's ranging from 33 to 86% and nitrodiols 11-12 with complete diastereoselectivity and e.e. > 95%. Nitrodiols (1S,7S)-11 and (1S,7S)-12 were then used as chiral precursors for the synthesis of the enantiopure 2,7-diphenyl- and 2,7-di-(2'-methoxyphenyl)-2,6-dioxaspiro[4.4]nonanes, 21 and 22, as EE/ZZ mixtures.