74058-58-5Relevant academic research and scientific papers
Synthesis of Vinca Alkaloids and Related Compounds, XXXIV: Synthesis of (3S,14S,16S)-Bromovincamines and Bromoapovincamines by Regioselective Bromination
Szabo, Lajos,Dobay, Laszlo,Kalaus, Gyoergy,Gacs-Baitz, Eszter,Tamas, Jozsef,Szantay, Csaba
, p. 781 - 789 (2007/10/02)
By bromimation of the iminium salt 2a (X=Cl), the 9-bromo derivative 2c (X=ClO4) is obtained in isomer-free state.Bromination of the lactam 8d leads to ca. 7.5:1 mixture of 11-bromo (8c) and 9-bromo (8a) lactams.These precursors have been used to synthesize 9-, 10- and 11-bromovincamines (11a-c), and 9-, 10- and 11-bromoapovincamines (12a-c).
1-Alkyl-9-bromohexahydroindolo quinolizium salts and use thereof to increase blood flow
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, (2008/06/13)
The invention is directed to 1-alkyl-9-bromohexagydro indoloquinolizium salts and a method for their use to increase blood circulation and decrease in blood vessel resistance.
