740792-70-5

Basic information

• Product Name: [ethyl(methyl)amino]acetic acid
• Synonyms: [ethyl(methyl)amino]acetic acid;Albb-004039;N-ethyl-N-methylglycine(SALTDATA: FREE);N-Ethyl-N-Methylglycine;2-(ethyl(methyl)amino)acetic acid
• CAS NO: 740792-70-5
• Molecular Formula: C5H11NO2
• Molecular Weight: 117.15
• Mol File: 740792-70-5.mol

Chemical Properties

• Boiling Point: 188.386°C at 760 mmHg
• Flash Point: 67.733°C
• Appearance: /
• Density: 1.037g/cm³
• Vapor Pressure: 0.268mmHg at 25°C
• Refractive Index: 1.452
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: [ethyl(methyl)amino]acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [ethyl(methyl)amino]acetic acid(740792-70-5)
• EPA Substance Registry System: [ethyl(methyl)amino]acetic acid(740792-70-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 740792-70-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
[ethyl(methyl)amino]acetic acid is used as an analgesic and anti-inflammatory agent for the treatment of conditions such as osteoarthritis and rheumatoid arthritis. It works by inhibiting the synthesis of prostaglandins, lipid compounds that promote inflammation and pain, thus providing relief to patients suffering from these conditions.
[ethyl(methyl)amino]acetic acid is typically administered orally, and its effects are usually seen within 1-2 hours of ingestion. Due to its safety and well-tolerated nature when used as directed, it is considered a reliable option for pain management. However, like any medication, it may have potential side effects and interactions with other drugs, which should be taken into consideration during its use.

InChI:InChI=1/C5H11NO2/c1-3-6(2)4-5(7)8/h3-4H2,1-2H3,(H,7,8)

Upstream product

• 59936-25-3 N-ethyl-N-methyl-glycine ethyl ester 
• 50-00-0 formaldehyd 
• 70732-64-8 2-{[(benzyloxy)carbonyl](ethyl)amino} acetic acid 
• 624-78-2 N-Ethylmethylamine 
• 79-11-8 chloroacetic acid 
• 107-97-1 sarcosine 
• 64-17-5 ethanol 

Relevant articles and documents

TRPV1 agonist, preparation method and application thereof

The present invention relates to a compound represented by a formula I, a stereoisomer, a tautomer, a solvate, a polymorph or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the compound, and a preparation method and a medical use of the compound, wherein the structure of the formula I is shown in the specification.

Electroactivated alkylation of amines with alcohols: Via both direct and indirect borrowing hydrogen mechanisms

A green, efficient N-alkylation of amines with simple alcohols has been achieved in aqueous solution via an electrochemical version of the so-called "borrowing hydrogen methodology". Catalyzed by Ru on activated carbon cloth (Ru/ACC), the reaction works well with methanol, and with primary and secondary alcohols. Alkylation can be accomplished by either of two different electrocatalytic processes: (1) in an undivided cell, alcohol (present in excess) is oxidized at the Ru/ACC anode; the aldehyde or ketone product condenses with the amine; and the resulting imine is reduced at an ACC cathode, combining with protons released by the oxidation. This process consumes stoichiometric quantities of current. (2) In a membrane-divided cell, the current-activated Ru/ACC cathode effects direct C-H activation of the alcohol; the resulting carbonyl species, either free or still surface-adsorbed, condenses with amine to form imine and is reduced as in (1). These alcohol activation processes can alkylate primary and secondary aliphatic amines, as well as ammonia itself at 25-70 °C and ambient pressure.

Synthesis of N-alkyl-N-methyl amino acids. Scope and limitations of base-induced N-alkylation of Cbz-amino acids

The reaction of N-benzyloxycarbonyl derivatives of aliphatic amino acids with NaH/alkyl iodides gave the corresponding N-Cbz-N-alkyl derivatives in good to high yields. The scope and limitations of this simple N-alkylation reaction were investigated as a convenient and flexible attempt to prepare unsymmetrically N,N-diprotected α-amino acids. The procedure is based on the N-alkylation of N-carbamoyl amino acids, a one-pot deprotection/protection sequence without extensive purification of the products. Protection of the carboxyl function is not required while the starting materials are inexpensive and commercially available.