7408-29-9

Upstream product

• 70972-99-5 4-(n-decyl)benzaldehyde 
• 104-72-3 decylbenzene 
• 60902-45-6 nonyltriphenylphosphonium bromide 
• 82532-71-6 methyl p-n-decylbenzoate 
• 54256-43-8 4-decylbenzoyl chloride 
• 38300-04-8 4-decylbenzoic acid 

Downstream Products

• 61440-56-0 p-decylbenzyl alcohol O-methanesulfonate 
• 1353054-45-1 C₃₀H₄₄O₃ 
• 1353054-46-2 (4-decylphenyl)(4-(2-(triisopropylsilyloxy)ethyl)phenyl)methanol 
• 1353054-41-7 2-(4-((4-decylphenyl)(hydroxy)methyl)phenyl)ethanol 
• 1353054-50-8 (S)-2-(tert-butoxycarbonylamino)-3-(2-(4-(4-decylbenzoyl)phenyl)acetamido)propanoic acid 
• 1353054-51-9 (S)-tert-butyl 3-(2-(4-(4-decylbenzoyl)phenyl)acetamido)-1-(hexadecylamino)-1-oxo-propan-2-ylcarbamate 
• 1353054-52-0 (S)-2-amino-3-(2-(4-(4-decylbenzoyl)phenyl)acetamido)-N-hexadecylpropanamide 
• 70972-99-5 4-(n-decyl)benzaldehyde 
• 162361-16-2 2-acetamido-2-(4-decylphenyl)propane-1,3-diol 
• 162359-27-5 2-(4-decylphenyl)-2-nitropropane-1,3-diol 
• 162361-15-1 2-amino-2-(4-decylphenyl)propane-1,3-diol 
• 162359-26-4 4-decylphenylnitromethane 
• 162359-25-3 4-decylbenzyl bromide 

Relevant academic research and scientific papers

Structural optimization and neurotrophic activity evaluation of neurotrophic gentiside derivatives

C14 alkyl benzoate ABG001, derived from naturally occurring gentisides, was reported to exhibit neurotrophic activity which is similar to NGF (Nerve Growth Factor). In this research, ABG001 was modified by the strategy of isosteric replacement and conformational restriction with the purpose of improving the bioactivity. The cellular neurotrophic activity of those ABG001 derivatives were evaluated, among which 3-hydroxyquinolin-2-(1H)-one A3 and 4-decylphenol ester B7 displayed much better neurotrophic activity compared with ABG001, which highlights the potential of those novel scaffolds for future neurotrophic agent development.

Benzophenone-containing fatty acids and their related photosensitive fluorescent new probes: Design, physico-chemical properties and preliminary functional investigations

Hydrophobic photoaffinity labeling is a powerful strategy to identify hydrophobic segments within molecules, in particular membrane proteins. Here we report the design and synthesis of a novel family of fluorescent and photosensitive lipid tools, which have a common amino acid scaffold functionalized by three groups: (i) a first fatty acid chain grafted with a photoactivatable benzophenone moiety (Fatty Acid BenzoPhenone, FABP), (ii) a second fatty acid chain to ensure anchoring into a half-bilayer or hydrophobic environment, and (iii) a fluorescent carboxytetramethylrhodamine headgroup (CTMR) to detect the photolabeled compound. We present data of the synthesis and characterization of three lipid tools whose benzophenone ring is situated at various distances from the central scaffold. We could therefore establish structure/properties relationships dependent upon the depth of insertion of benzophenone into the membrane. Our lipid tools were extensively characterized both physico- and bio-chemically, and we assessed their functionality in vitro using bacterioRhodopsin (bR). We thus provide the scientific community with novel and reliable tools for the identification and study of hydrophobic regions in proteins.

Synthesis and immunosuppressive activity of 2-substituted 2- aminopropane-1,3-diols and 2-aminoethanols

A series of 2-substituted 2-aminopropane-1,3-diols was synthesized and evaluated for their lymphocyte-decreasing effect and immunosuppressive effect on rat skin allograft. A phenyl ring was introduced into the alkyl chain of the lead compound 3, which is an immunosuppressive agent structurally simplified from myriocin (1, ISP-I) via compound 2. The potency of the various compounds was dependent upon the position of the phenyl ring within the alkyl side chain. The most suitable length between the quaternary carbon atom and the phenyl ring was two carbon atoms. 2-Substituted 2-aminoethanols were successively synthesized and evaluated for their T-cell-decreasing effect and immunosuppressive effect using a popliteal lymph node gain assay in rats. The absolute configuration at the quaternary carbon affected the activity, and the (pro-S)-hydroxymethyl group of compound 6 was essential for potent immunosuppressive activity. Favorable substituents for the (pro-R)- hydroxymethyl group of 6 were hydroxyalkyl (hydroxyethyl and hydroxypropyl) or lower alkyl (methyl and ethyl) groups. 2-Amino-2-[2-(4- octylphenyl)ethyl]propane-1,3-diol hydrochloride (6, FTY720) was found to possess considerable activity and is expected to be useful as an immunosuppressive drug for organ transplantation.

ARYL ALIPHATIC ACIDS

Novel aryl aliphatic acids or derivatives thereof of the general formula R-(Cx-Cy)-(CmH2m)-G-C(R1)2-Ar-(CnH2n)-COOR2 are described which exhibit inhibiting activity against 12-lipoxygenase. The compounds are characterized by having a low level of toxicity. Also included are salts and esters of the aliphatic acids

Sebosuppressive preparations containing benzyl alcohol derivatives

Sebosuppressive cosmetic preparations containing benzyl alcohol derivatives which are substituted on the benzene ring by alkyl, aryl, alkyloxymethyl radicals or by a fused aromatic ring, and methods for their use.

Antilipidemic para-[aryl(alkyl or alkenyl)amino]-benzoic acid derivatives

Novel para-[aryl(alkyl or alkenyl)amino]benzoic acids, esters, pharmaceutically acceptable salts and pharmaceutical compositions thereof and a method of lowering serum lipid levels in mammals therewith.