740812-89-9Relevant academic research and scientific papers
Synthesis and fungicidal activity of enantiomerically pure (R)- and (S)-silicon-containing azole fungicides
Itoh, Hiroyuki,Furukawa, Youji,Tsuda, Mikio,Takeshiba, Hideo
, p. 3561 - 3567 (2007/10/03)
Enantiomerically pure (R)- and (S)-1-(1H-1,2,4-triazol-1-yl)-2-(4- fluorophenyl)-3-trimethylsilylpropan-2-ol 1 were prepared via an enantioselective Grignard reaction. The absolute stereochemistry of 1 was determined by X-ray analysis. In a comparison of in vitro antifungal activities of the enantiomers, the (-)-enantiomer with the R-absolute configuration was far more potent than the (+)-enantiomer.
