740812-90-2

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 740812-89-9 2-(4-fluorophenyl)-3-trimethylsilylpropan-1,2-diol 
• 2251-76-5 2-(4-fluorophenyl)-2-oxoacetic acid 

Relevant academic research and scientific papers

Synthesis and fungicidal activity of enantiomerically pure (R)- and (S)-silicon-containing azole fungicides

Enantiomerically pure (R)- and (S)-1-(1H-1,2,4-triazol-1-yl)-2-(4- fluorophenyl)-3-trimethylsilylpropan-2-ol 1 were prepared via an enantioselective Grignard reaction. The absolute stereochemistry of 1 was determined by X-ray analysis. In a comparison of in vitro antifungal activities of the enantiomers, the (-)-enantiomer with the R-absolute configuration was far more potent than the (+)-enantiomer.