740835-10-3

Basic information

• Product Name: 2-(N-(3-hydroxy-4-methoxyphenyl)sulfamoyl)acetic acid
• Synonyms: 2-(N-(3-hydroxy-4-methoxyphenyl)sulfamoyl)acetic acid
• CAS NO: 740835-10-3
• Molecular Weight: 261.255
• Mol File: 740835-10-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(N-(3-hydroxy-4-methoxyphenyl)sulfamoyl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(N-(3-hydroxy-4-methoxyphenyl)sulfamoyl)acetic acid(740835-10-3)
• EPA Substance Registry System: 2-(N-(3-hydroxy-4-methoxyphenyl)sulfamoyl)acetic acid(740835-10-3)

Safety Data

• Hazardous Substances Data: 740835-10-3(Hazardous Substances Data)

Upstream product

• 1445727-01-4 ethyl 2-(N-(3-hydroxy-4-methoxyphenyl)sulfamoyl)acetate 
• 1687-53-2 5-amino-2-methoxyphenol 
• 740834-96-2 (3-hydroxy-4-methoxy-phenylsulfamoyl)-acetic acid methyl ester 

Downstream Products

• 1445726-75-9 (E)-4-(4-(2-(N-(3-hydroxy-4-methoxyphenyl)sulfamoyl)vinyl)-3,5-dimethoxyphenoxy)butanoic acid 
• 865784-07-2 (E)-N-(3-hydroxy-4-methoxyphenyl)-2-(2,4,6-trimethoxyphenyl)ethenesulfonamide 
• 1445727-08-1 N-(3-hydroxy-4-methoxyphenyl)-2-oxo-2-(2,4,6-trimethoxyphenyl)ethanesulfonamide 
• 1445727-05-8 2-(N-(3-hydroxy-4-methoxyphenyl)sulfamoyl)acetyl chloride 
• 865784-24-3 (E)-2-methoxy-5-(2-(2,4,6-trimethoxyphenyl)vinylsulfonamido)phenyl dihydrogen phosphate 
• 908344-58-1 2-hydroxy-N-(3-hydroxy-4-methoxyphenyl)-2-(2,4,6-trimethoxyphenyl)ethanesulfonamide 

Relevant articles and documents

Synthesis and evaluation of antiepileptic activity of newly designed coumarin-sulfonamide hybrids

The combination of different heterocyclic rings to form a multifunctional compound is a new approach to get the potent and selective compounds, which can act as antiepileptic drugs. In this study we designed and synthesized the hybrid of the coumarin ring with sulfonamide moiety. Coumarin sulfonamide hybrids (CS1-CS7) were synthesized by Knoevenagel condensation of methyl anilinosulfonyl acetate with substituted salicyaldehyde in the presence of catalytic base. The synthesized hybrid compounds were characterized by means of mass, 1H & 13C NMR and FTIR spectroscopy, moreover antiepileptic activity was screened through seizure model of epilepsy using pentylenetetrazole and maximal electroshock. According to results, compound CS-2 remained to be highest potent and presented significant protection at 60 mg/kg in both the seizure models. Furthermore, compound CS-2 was also evaluated for biochemical and a histopathological study in which no significant results were obtained. In addition to former activities, compound CS-2 was also examined for liver toxicity.

Synthesis of new coumarin 3-(N-aryl) sulfonamides and their anticancer activity

Synthesis of coumarin 3-(N-aryl) sulfonamides was accomplished either by Knoevenagel condensation of anilinosulfonylacetic acids with suitable salicylaldehydes or by the reaction of methyl anilinosulfonylacetates with substituted salicylaldehydes in presence of a catalytic amount of a base. All the compounds tested for antiproliferative activity in different cancer cell lines have shown GI50 values less than 100μM.